- 11G10SC (See other available formats)
- Other Names
- TRIM28 pS473, KAP-1 pS473
- Mouse IgG1, κ
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- Product Citations
Transcriptional intermediary factors (TIFs) are a group of transcriptional coactivators and corepressors that regulate gene expression by modulating chromatin structure and assembly of transcription initiation complexes. TIF1β is a member of the TIF1 subfamily of chromatin-associated TIFs that play a key role in many developmental and physiological processes. Studies using knockout mice reveal the important function of TIF1β in regulating genomic imprinting, T cell activation, and T cell tolerance.Product Details
- Antibody Type
- Host Species
- Modified peptide: VKRSRpSGEGEVC.
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
WB - Quality tested
IF - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2561781 (BioLegend Cat. No. 654101)
AB_2561782 (BioLegend Cat. No. 654102)
- An N-terminal RING-B box coiled coil (RBCC) domain most likely attributes to intermolecular structure, while two characteristic chromatin-targeting domains, a plextrin homology (PH) finger motif and bromodomain, are found in the C-terminus.
- TIF1β acts as a transcriptional repressor by modulating histone deacetlyation, histone H3 Ly-9 methylation, and recruitment of HP1 proteins.
- TIF1β was shown to form homo-oligomers in vitro, but does not form hetero-oligomers with TIF1α or TIF1γ.
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Transcription Factors
- Molecular Family
- Antigen References
1. Messerschmidt DM, et al. 2012. Science 335:1499.
2. Chikuma S, et al. 2012. Nat. Immunol. 13:596.
- Gene ID
- 21849 View all products for this Gene ID
- View information about TIF1β on UniProt.org
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