Purified anti-mouse/rat β-Amyloid Antibody (Previously Covance catalog# SIG-39151)

Pricing & Availability
Clone
Poly18058 (See other available formats)
Other Names
Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Previously
Signet Catalog# 9151-02
Signet Catalog# 9151-05
Signet Catalog# 9151-10
Covance Catalog# SIG-39151
Isotype
Rabbit Polyclonal IgG
Ave. Rating
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Product Citations
publications
Cat # Size Price Save
826801 200 µl ¥133,900
Description

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids in length that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as "seeds")  which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.

Product Details
Technical data sheet

Product Details

Reactivity
Mouse, Rat
Antibody Type
Polyclonal
Host Species
Rabbit
Formulation
IgG Fraction (in PBS; no preservatives or carrier proteins).
Preparation
The antibody was purified by affinity chromatography.
Concentration
1.0 mg/ml
Storage & Handling
Do not store antibody diluted below 50 ug/mL in the absence of protein (i.e.: add 2% bovine serum albumin). The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

ELISA

Recommended Usage

The optimal working dilution should be determined for each specific assay condition.

Application Notes

This antibody is effective in ELISA

BioLegend’s rabbit anti-Amyloid beta is specific for the Aβ. The rabbit anti-rodent Aβ reacts extremely well with all isoforms. The rabbit anti-rodent Aβ antibody has been reported to have negligible cross-reactivity to human Aβ using immunohistochemistry2.


This product may contain other non-IgG subtypes.

Application References

(PubMed link indicates BioLegend citation)
  1. van Groen T, et al. Transformation of diffuse beta-Amyloid precursor protein and beta-Amyloid deposits to placques in the thalamus after transient occlusion of the middle cerebral artery in rats. Stroke 36(7):1551-6, 2005.
  2. Thomas van Groen, et al. 2006. Neurobiology of Disease. 23:653. (IHC) PubMed
Product Citations
  1. Zhu HL, et al. 2019. Front Neurosci. 12:962. PubMed
Publication Library
RRID
AB_2564905 (BioLegend Cat. No. 826801)

Antigen Details

Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family
APP/β-Amyloid
Gene ID
351 View all products for this Gene ID
UniProt
View information about beta-Amyloid on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 4    Revision Date: 05/21/2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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