- W19330E (See other available formats)
- Regulatory Status
- Other Names
- CSF-1R, M-CSR, c-fms
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse CD115 transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone W19330E does not affect binding of clone W19330C on target cells.
Clone W19330E can block clone AFS98 binding on target cells.
Clone W19330E can block ligand binding to CSFR-1.
AB_2910351 (BioLegend Cat. No. 165202)
- Ig superfamily, 145 kD
Monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, osteoclasts
- Growth factor receptor, tyrosine kinase
- Macrophage colony stimulating factor (M-CSF), IL-34
- Cell Type
- Dendritic cells, Macrophages, Monocytes, Osteoclasts
- Biology Area
- Cell Biology, Immunology, Stem Cells
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
- Guilbert LJ and Stanley ER. 1980. J Cell Bio. 85:153-9.
- Yeung Y-G, et al. 1978. Proc Natl Acad Sci. 84:1268-71.
- Sherr CJ, et al. 1985. Cell. 41:665-76.
- Gene ID
- 12978 View all products for this Gene ID
- View information about CD115 on UniProt.org
|Purified anti-mouse CD115 (CSF-1R)||W19330E||FC|
|PE anti-mouse CD115 (CSF-1R)||W19330E||FC|
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