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Purified anti-human CD83 Recombinant Antibody

Pricing & Availability
Clone
QA21A26 (See other available formats)
Regulatory Status
RUO
Other Names
CD83, HB15, hCD83, BL11
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA21A26_PURE_CD83_Antibody_041422
Human monocyte-derived dendritic cells (induced with GM-CSF and IL-4 and TNF-α) stained with purified anti-human CD83 recombinant (clone QA21A26) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by PE anti-mouse IgG.
  • QA21A26_PURE_CD83_Antibody_041422
    Human monocyte-derived dendritic cells (induced with GM-CSF and IL-4 and TNF-α) stained with purified anti-human CD83 recombinant (clone QA21A26) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by PE anti-mouse IgG.
Cat # Size Price Save
382902 100 µg ¥40,260
Description

CD83, also known as B-cell activation protein and Cell surface protein HB15, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. CD83 may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2927817 (BioLegend Cat. No. 382902)

Antigen Details

Structure
Ig superfamily, single chain transmembrane glycoprotein, 43 kD
Distribution

Dendritic cells, Langerhan cells, activated B and T cells

Function
Membrane-bound CD83 is of immune stimulatory capacity, activates T-cells and is important for the generation of thymocytes; the soluble CD83 has the opposite effect and has an immune inhibitory capacity. The transmembrane domain of membrane-bound CD83 stabilizes MHC II, costimulatory molecules and CD28 in the membrane by antagonizing MARCH-family E3 ubiquitin ligases.
Interaction
Treg, Dendritic cells, B cells
Cell Type
B cells, Dendritic cells, Langerhans cells, T cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Zhou LJ, et al. 1992. J Immunol. 149:735-42.
  2. Zhang Z, et al. 2004. Protein Sci. 13:2819-24.
Gene ID
9308 View all products for this Gene ID
UniProt
View information about CD83 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 04/14/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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