- O99E5 (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG1
- Ave. Rating
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- Product Citations
CD105 (Endoglin) is expressed by endothelial cells, pro-fibrogenic cells and hepatic stellate cells; it plays important roles in endothelial proliferation and cardiovascular development. Mutations in the ENG gene lead to Hereditary Hemorrhagic Telangiectasia, a disorder characterized by arteriovenous malformations. An extracellular domain of the full-length membrane endoglin, soluble endoglin, is a proposed biomarker of cardiovascular disease progression, cardiovascular disease treatment and endothelial dysfunction. Endoglin is also expressed in the syncytiotrophoblast throughout pregnancy, but transiently upregulated in the extravillous trophoblast of anchoring villi. Furthermore, endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis.Product Details
- Antibody Type
- Host Species
- Full length recombinant protein of human Endoglin/CD105 expressed in HEK293T.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Does not react with mouse.
AB_2572089 (BioLegend Cat. No. 684102)
- 658 amino acid with the predicted molecular weight of approximately 71kD.
Endothelial cells, mesangial cells, cardiac and scleroderma fibroblasts, and hepatic stellate cells.
- Endoglin plays important roles in endothelial proliferation and cardiovascular development.
- TGFBR1, TGFBR2, TGF-beta 1, TCTEX1D4, ARRB2 and GDF2.
- TGF-β1, TGF-β3.
- Cell Type
- Endothelial cells, Fibroblasts
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cancer Biomarkers, Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Rathouska J, et al. 2015. Atherosclerosis 243:383.
2. Kapur NK, et al. 2013. Vasc. Health Risk Manag. 9:195.
3. Meurer SK, et al. 2014. World J. Biol. Chem. 5:180.
4. Gregory AL, et al. 2014. Placenta 35:S93-9.
5. Nassiri F, et al. 2011. Anticancer Res. 31:2283.
5. Zhang Y, et al. 2011. Int. J. Clin. Exp. Med. 4:32-42.
- Gene ID
- 2022 View all products for this Gene ID
- View information about CD105 on UniProt.org
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