- 14F2 (See other available formats)
- Other Names
- BH3 domain-only protein, BH3 interacting domain death agonist
- Rat IgG2a
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- Product Citations
BID, a BH3 interacting domain death agonist, is a member of the Bcl-2 family. Upon activation, in response to Fas/TNF-R1 death receptor signal, it is cleaved by caspase 8 and translocated to mitochondria. There it induces cytochrome C release, which in turn activates downstream caspases.Product Details
- Antibody Type
- Host Species
- Recombinant BID fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1-2 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Kang SJ, et al. 2002. Cell. Death Differ. 9:1115.
- Li H, et al. 1998. Cell 94:491.
AB_2063468 (BioLegend Cat. No. 645001)
- A 22 kD protein, contains only BH3 domain, but not the BH1, Bh2 and BH4 found in other Bcl-2 family members. BID does not contain C-terminal hydrophobic region characteristic of membrane bound Bcl-2 family.
Cytoplasmic, inside mitochondria once activated.
- Activated by caspase 8 in response to Fas/TNF-R1 death receptor signals.
- Caspase 8, BAK
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology
- Antigen References
1. Wang K, et al. 1996. Genes Dev. 10:2859
- Gene ID
- 637 View all products for this Gene ID
- View information about BID on UniProt.org
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