- P81B6 (See other available formats)
- Regulatory Status
- Other Names
- V-Akt Murine Thymoma Viral Oncogene Homolog 2, Protein Kinase B Beta, Rac Protein Kinase Beta, RAC-PK-Beta, PKB Beta, PRKBB, PKBB, HIHGHH, PKBBETA, RAC-BETA
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
AKT (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis, and tumor formation. There are three isoforms of AKT- AKT1, 2, and 3, which are also known as PKBα, β, and γ). Increasing evidence suggests that AKT1, 2, and 3 plays an unique role in breast cancer initiation and progression. AKT2 is amplified or overexpressed in cancer with a higher frequency than those found with AKT1. AKT2 is also closely linked to Type II diabetes and is a pivotal player in the Phosphatidylinositol 3 kinase/Akt/Mammalian target of rapamycin (PI3K/mTOR) signaling axis. The deregulation of AKT2 has been associated with acquisition of stem cell-like properties, responsible for invasiveness and tumor progression, metastatic spread, and chemoresistance.Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Host Species
- Purified recombinant fragment (a.a. 2-149) of human AKT2 expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2566344 (BioLegend Cat. No. 680202)
- 481 amino acids with a predicted molecular weight of approximately 56 kD.
Cytoplasm, nucleus, cell membrane, and peripheral membrane protein.
- AKT2 plays a ket role in regulating cell survival, insulin, signaling, angiogenesis, and tumor formation.
- BTBD10, KCTD20, MTCP1, TCL1A, TCL1B, CLK2, PBH2, TRAF6, and CLIP3.
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Immunology, Innate Immunity, Neuroscience, Signal Transduction, Ubiquitin/Protein Degradation
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
1. Pereira L, et al. 2015. Drug Discov. Today 9:1152-8.
2. Yu H, et al. 2015. Vascul. Pharmacol. 71:57-64.
3. Cohen MM Jr. 2013. Am J. Med Genet A. 12:2931-7.
4. Dillon RL, Muller WJ. 2010. Cancer Res. 11:4260-4.
5. Song G, et al. 2005. J. Cell Mol. Med. 1:59-71.
- Gene ID
- 208 View all products for this Gene ID
- View information about AKT2 on UniProt.org
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