- Poly6379 (See other available formats)
- Other Names
- 14-3-3E, YWHAE
- Rabbit Polyclonal IgG
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- Product Citations
14-3-3ε is a 29 kD protein that belongs to the family of 14-3-3 proteins. This family of proteins mediates signal transduction and cell cycle progression by binding to phosphoserine and phosphothreonine motifs on a large number of target molecules. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases as well as protein kinase C. There are eight known isoforms of 14-3-3: alpha, beta, gamma, delta, epsilon, zeta, eta, and theta.Product Details
- Human, Cross-Reactivity: Mouse (weak)
- Antibody Type
- Host Species
- Full length human 14-3-3 epsilon recombinant protein
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
- The antibody was purified by antigen-affinity chromatography.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- Upon receipt, store frozen at -20°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The Poly6379 antibody has been shown to be useful for western blotting of human 14-3-3 epsilon protein.
This product may contain other non-IgG subtypes.
This clone may also recognize other 14-3-3 family members.
- Product Citations
AB_2217770 (BioLegend Cat. No. 637901)
- 14-3-3 protein superfamily, homodimer, 29 kD
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
- BCL2, Calmodulin 1, CDC25A/B, CDK11, IGFIR, IRS1, IRS2, MEKK3, Raf-1, c-Src,
- Biology Area
- Cell Biology, Signal Transduction
- Antigen References
1. Jin DY, et al. 1996. Nature 382:308.
2. Conklin DS, et al. 1995. Proc. Natl. Acad. Sci. USA 92:7892.
3. Zannis-Hadjopoulos M, et al. 2008. Trends Biochem. Sci. 33:44.
- Phosphorylation disrupts dimerization
- Gene ID
- 36059 View all products for this Gene ID
- View information about 14-3-3e on UniProt.org
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