PE anti-P2RY12 Antibody

Pricing & Availability
S16007D (See other available formats)
Regulatory Status
Other Names
P2Y12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12
Rat IgG2b, κ
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Product Citations
Brain from a C57BL/6 mouse was digested with collagenase and microglial cells were enriched with a percoll gradient and then stained with CX3CR1 APC and P2RY12 (clone S16007D) PE (top) or rat IgG2b, κ PE isotype control (bottom).
  • S16007D_PE_P2RY12_Antibody_1_011518
    Brain from a C57BL/6 mouse was digested with collagenase and microglial cells were enriched with a percoll gradient and then stained with CX3CR1 APC and P2RY12 (clone S16007D) PE (top) or rat IgG2b, κ PE isotype control (bottom).
  • S16007D_PE_P2RY12_Antibody_2_011518
Compare all formats See PE spectral data
Cat # Size Price Save
848003 25 µg ¥28,980
848004 100 µg ¥63,630

Purinergic Receptor P2Y (P2RY12) is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. P2RY12 is not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. P2RY12 is a highly selective marker for microglia that specifically distinguishes these cells from other myeloid cells.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
Mouse P2RY12.
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

View the video of our collaborator discussing the importance of highly specific monoclonal antibodies for P2RY12 in Microglia research.

Learn more about the validation testing we performed on clone S16007D by watching our Scientific Poster Video.

Additional Product Notes

View more applications data for this product in our Scientific Poster Library.

Product Citations
  1. Chitu V, et al. 2020. Cell Reports. 30(9):3004-3019. PubMed
  2. Honarpisheh P, et al. 2020. J Neuroinflammation. 0.9625. PubMed
  3. Burns JC, et al. 2020. eLife. 9:00. PubMed
  4. Liu Y, et al. 2020. Cell. 183(6):1665-1681.e18. PubMed
AB_2721644 (BioLegend Cat. No. 848003)
AB_2721645 (BioLegend Cat. No. 848004)

Antigen Details

P2RY12 is a 347 amino acid protein with a molecular mass of 39.8 kD.

Tissue distribution: platelets, brain (microglia), lung, appendix, pituitary and adrenal glands.
Cellular distribution: cell membrane and cytosol.

G-protein coupled receptor that inhibits the adenylyl cyclase second messenger system.
ADP and ATP.
Cell Type
Microglia, Platelets
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
GPCR, Purinergic Receptors
Antigen References

1. Orr AG, et al. 2009. Nat. Neurosci. 12(7):872-8.

Gene ID
70839 View all products for this Gene ID
View information about P2RY12 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 01/31/2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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