PE anti-mouse IL-23R Antibody anti-IL-23R

Clone: 12B2B64 (See other available formats)
Regulatory Status: RUO
Other Names: Interleukin 23 Receptor, IL-23 Receptor, IL-23R, IBD17
Isotype: Rat IgG2b, κ
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12B2B64_PE_IL23R_Antibody_032816 — Th17-polarized cells from C57BL/6 mouse lymph nodes were stained with IL-23R (clone 12B2B64) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram).

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Cat #	Size	Price	Save
150903	25 µg	¥33,660
150904	100 µg	¥73,700

Description

IL-23R is a 72 kD protein that associates with IL-12RB1 to form a heterodimer. It is a ligand for IL-23 and stimulates T, NK and some myeloid cells. It is necessary for generation of Th17 cells but is not required for maintenance of previously generated Th17 cells. Expression of IL-23R or mutations in the IL23R gene has been associated with autoimmunity and may also be important in tumor biology.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Partial mouse IL-23R recombinant protein (aa 24-374)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2572188 (BioLegend Cat. No. 150903)
AB_2572189 (BioLegend Cat. No. 150904)

Antigen Details

Structure: 72 kD protein that associates with IL-12RB1 to form a heterodimer.
Function: Involved in IL-23A signaling.
Interaction: JAK2 and STAT3.
Ligand/Receptor: IL-23/IL23A.
Biology Area: Immunology
Molecular Family: Cytokine/Chemokine Receptors
Antigen References: 1. Parham C, et al. 2002. J. Immunol. 168:5699.
2. Schmechel S, et al. 2008. Inflamm. Bowel Dis. 14:204.
3. Harris TJ, et al. 2007. J. Immunol. 179:4313.
4. Zhang XY, et al. 2006. Immunogenetics 57:934.
5. Awasthi A, et al. 2009. J. Immunol. 182:5904.
Gene ID: 209590 View all products for this Gene ID
UniProt: View information about IL-23R on UniProt.org

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Related FAQs

What type of PE do you use in your conjugates?: We use R-PE in our conjugates.

Other Formats

View All IL-23R Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse IL-23R	12B2B64	FC
PE anti-mouse IL-23R	12B2B64	FC
APC anti-mouse IL-23R	12B2B64	FC
Brilliant Violet 421™ anti-mouse IL-23R	12B2B64	FC
TotalSeq™-A1033 anti-mouse IL-23R	12B2B64	PG
TotalSeq™-C1033 anti-mouse IL-23R	12B2B64	PG

Certificate of Analysis

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Go To Top Version: 1 Revision Date: 03/28/2016

For Research Use Only. Not for diagnostic or therapeutic use.

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