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PE anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
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Product Citations
publications
BM8_PE_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 PE
  • BM8_PE_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 PE
Compare all formats See PE spectral data
Cat # Size Price Save
123109 25 µg ¥9,460
123110 100 µg ¥31,020
Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  2. Tan T, et al. 2019. Nat Commun. 10:3322. PubMed
  3. Man SM et al. 2016. Cell. 167(2):382-396 . PubMed
  4. Zhao Y, et al. 2019. Mucosal Immunol. 1.298611111. PubMed
  5. Wang Q, et al. 2019. FASEB Bioadv. 1:609. PubMed
  6. Gordan S, et al. 2020. Cell Reports. 29(10):3033-3046.e4.. PubMed
  7. Wang L, et al. 2021. J Nanobiotechnology. 19:56. PubMed
  8. Hasan Z, et al. 2013. Am J Physiol Lung Cell Mol Physiol. 304:221. PubMed
  9. Lee T, et al. 2014. Mol Biol Cell. 25:583. PubMed
  10. Peterson T, et al. 2016. Proc Natl Acad Sci U S A. 113: 4470-4475. PubMed
  11. Wang L, et al. 2020. Front Cell Dev Biol. 0.745138889. PubMed
  12. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  13. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  14. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
  15. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  16. Fu R, et al. 2020. Sci Rep. 10:1455. PubMed
  17. Groza D, et al. 2018. Oncoimmunology. 7:e1424676. PubMed
  18. Kim SS, et al. 2022. Cancers (Basel). 14:. PubMed
  19. Yildirim Z, et al. 2022. EMBO Mol Med. 14:e15344. PubMed
  20. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  21. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  22. Gan C, et al. 2022. Respir Res. 23:32. PubMed
  23. El-Hindi K, et al. 2022. Int J Mol Sci. 23:. PubMed
  24. Meng W, et al. 2021. JCI Insight. 6:. PubMed
  25. Pathak JL, et al. 2021. Front Cell Dev Biol. 628139:9. PubMed
  26. Huang J, et al. 2021. Immunity. 54(4):673-686.e4. PubMed
  27. Kaczanowska S, et al. 2021. Cell. 184(8):2033-2052.e21. PubMed
  28. Karki R, et al. 2016. Nature. 10.1038/nature20597. PubMed
  29. Kokona D, et al. 2016. Exp Eye Res. S0014-4835(16)30499-7. PubMed
  30. Kloepper J, et al. 2016. Proc Natl Acad Sci U S A. 113: 4476-4481. PubMed
  31. O'Donnell C, et al. 2015. Br J Cancer. 114: 37 - 43. PubMed
  32. Maltby S, et al. 2014. J Immunol. 193:4072. PubMed
  33. Jackson A, et al. 2014. J Leukoc Biol. 92:609. PubMed
  34. Guo HX, et al. 2018. World J Gastroenterol. 24:1779. PubMed
  35. Karki R et al. 2018. Cell. 173(4):920-933 . PubMed
  36. Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
  37. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  38. Li Y, et al. 2021. Basic Res Cardiol. 116:30. PubMed
  39. Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed
  40. Morgan PK, et al. 2021. J Biol Chem. 297:101341. PubMed
  41. Yang C, et al. 2021. J Immunother Cancer. 9:. PubMed
  42. Shen Y, et al. 2021. Comput Struct Biotechnol J. 19:5360. PubMed
  43. Zhang J, et al. 2021. Front Cardiovasc Med. 8:737652. PubMed
  44. Matsushita Y, et al. 2021. J Bone Miner Res. 36:1145. PubMed
  45. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  46. de Groot AE, et al. 2021. Prostate. 81:629. PubMed
  47. Palacios LM, et al. 2022. Biology (Basel). 11:. PubMed
  48. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  49. Clark K, et al. 2015. J Autoimmun. Available online 21 August 2015. PubMed
  50. Yu S, et al. 2016. J Immunol. 197: 256 - 265. PubMed
  51. Aguilera T, et al. 2016. Nat Commun. 7:13898. PubMed
  52. Harel M, et al. 2020. Cell. 179(1):236-250.e18.. PubMed
  53. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  54. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  55. Agelidis A, et al. 2019. Front Immunol. 10:500. PubMed
  56. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  57. Truax AD et al. 2018. Cell host & microbe. 24(3):364-378 . PubMed
  58. Rashid K, et al. 2018. Sci Rep. 8:9023. PubMed
  59. Chen J, et al. 2022. Nat Commun. 13:6759. PubMed
  60. Wang S, et al. 2022. Front Immunol. 13:869061. PubMed
  61. Gopinathan G, et al. 2022. Mol Cancer Ther. 21:1030. PubMed
  62. Wang Q, et al. 2020. Wound Repair Regen. 28:105. PubMed
  63. Yu X, et al. 2021. Nature. 594:560. PubMed
  64. Wei Q, et al. 2021. Nat Commun. 12:2522. PubMed
  65. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  66. Jenull S, et al. 2021. Cell Reports. 36(3):109406. PubMed
  67. Yuan Q, et al. 2021. Cell Reports. 34(5):108724. PubMed
  68. Acharya N, et al. 2020. Immunity. 53(3):658-671.e6. PubMed
  69. Barberio AE, et al. 2020. ACS Nano. 14:11238. PubMed
  70. Liang W, et al. 2020. Nat Commun. 4.563888889. PubMed
  71. Li T, et al. 2016. Cell Death Dis. 7:e2258. PubMed
  72. Elbaz M, et al. 2015. Mol Oncol. 9: 906-919. PubMed
  73. Tang E, et al. 2015. J Lipid Res. 56:358. PubMed
  74. Liao Y, et al. 2017. Virol J. 10.1186/s12985-017-0801-x. PubMed
  75. Dong G, et al. 2017. Biochim Biophys Acta. 10.1016/j.bbadis.2017.08.005. PubMed
  76. Tamura R, et al. 2017. Inflamm Regen. 36:26:00. PubMed
  77. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  78. Demircioglu F, et al. 2020. Nat Commun. 11:1290. PubMed
  79. Kimura T, et al. 2020. Commun Biol. 0.527777778. PubMed
  80. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  81. Almutairi F, et al. 2021. Front Immunol. 12:772288. PubMed
  82. Dignum T, et al. 2021. Cell Rep. 36:109675. PubMed
  83. Hoffman D, et al. 2021. Immunity. 54:2712. PubMed
  84. Sugimoto C, et al. 2022. Elife. 11:. PubMed
  85. Nabeta HW, et al. 2022. Front Cell Infect Microbiol. 12:976033. PubMed
  86. Liu Z, et al. 2015. Biol Reprod. 92:63. PubMed
  87. Nasser MW, et al. 2015. Cancer Res . 75: 974-985. PubMed
  88. Liu Y, et al. 2015. Sci Rep. 5:17215. PubMed
  89. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  90. Tencati M, Tapping R 2016. Infect Immun . 84: 2904 - 2913. PubMed
  91. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  92. Sun P, et al. 2021. J Invest Dermatol. 141:1542. PubMed
  93. Li Y, et al. 2022. Clin Transl Immunology. 11:e1362. PubMed
  94. Sugita J, et al. 2021. Nat Commun. 12:1910. PubMed
  95. Han C, et al. 2021. Cell Reports. 34(6):108706. PubMed
  96. Kovacs L, et al. 2020. PLoS One. 15:e0240455. PubMed
  97. Oghumu S, et al. 2014. Immunology. 143: 109-119. PubMed
  98. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  99. Hyatt L, et al. 2014. PLoS One. 9:109072. PubMed
  100. Lumbroso D, et al. 2018. Front Immunol. 9:358. PubMed
  101. Simonneau M, et al. 2018. Oncotarget. 9:36457. PubMed
  102. Samarchith P Kurup et al. 2019. Cell host & microbe. 25(4):565-577 . PubMed
  103. Yuan B, et al. 2021. J Immunother Cancer. 9:. PubMed
  104. Wu X, et al. 2021. Elife. 10:. PubMed
  105. Wang B, et al. 2022. Nat Commun. 13:3821. PubMed
  106. Opzoomer JW, et al. 2021. Sci Adv. 7:eabg9518. PubMed
  107. Glass A, et al. 2013. J Immunol. 190:4830. PubMed
  108. Izquierdo-Useros N, et al. 2014. J Immunol . 192:4852-4858. PubMed
  109. Zhang Y, et al. 2015. PLoS Pathog. 11: e1005167. PubMed
  110. Liu Z, et al. 2016. J Biol Chem. 291: 1441 - 1447. PubMed
  111. Cheng XS, et al. 2020. J Cell Mol Med. 24:8391. PubMed
  112. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  113. Barman PK, et al. 2019. J Immunol. 202:2720. PubMed
  114. Das LM, et al. 2019. Autophagy. 15:813. PubMed
  115. Pelka K, et al. 2018. Immunity. 48:911. PubMed
  116. Lim D, et al. 2018. Front Physiol. 9:47. PubMed
  117. Kang SJ, et al. 2022. Food Sci Anim Resour. 42:903. PubMed
  118. Lee J, et al. 2022. Nat Commun. 13:1516. PubMed
  119. Ma K, et al. 2021. J Leukoc Biol. 110:927. PubMed
  120. Kornstädt L, et al. 2021. Front Immunol. 11:607048. PubMed
  121. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  122. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  123. Wang H, et al. 2021. Malar J. 20:249. PubMed
  124. Wang Q, et al. 2020. Res Sq. . PubMed
  125. Hofbauer D, et al. 2021. Immunity. 54(8):1772-1787.e9. PubMed
  126. Lin J, et al. 2017. Sci Rep. 7:41722. PubMed
  127. Yin T, et al. 2016. Sci Rep. 18:19534. PubMed
  128. Mitsuhashi A, et al. 2015. Nat Commun. 6: 8792. PubMed
  129. Eichin D, et al. 2015. PLoS One. 10: 0134721. PubMed
  130. Kumaran Satyanarayanan S, et al. 2019. Nat Commun. 10:3471. PubMed
  131. Codina A, et al. 2019. Cell Syst. 8:136. PubMed
  132. Iizasa E, et al. 2021. Nat Commun. 12:2299. PubMed
  133. Hu M, et al. 2021. J Clin Invest. 131:. PubMed
  134. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  135. Chen W, et al. 2016. J Immunol. 197: 3554 - 3565. PubMed
  136. Enam SF, et al. 2020. J Neuroinflammation. 0.845138889. PubMed
  137. Li N, et al. 2021. eLife. 10:00. PubMed
  138. Penninger P, et al. 2021. STAR Protocols. 2(1):100352. PubMed
  139. Zhang F, et al. 2020. EMBO Mol Med. e12034:12. PubMed
  140. Abdul Pari AA, et al. 2020. Cancer Res. 80:2586. PubMed
  141. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  142. Wang C, et al. 2017. J Ethnopharmacol. 10.1016/j.jep.2017.06.014. PubMed
  143. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  144. Yong L, et al. 2022. Nat Commun. 13:4255. PubMed
  145. Xu M, et al. 2022. Genes Dis. 9:429. PubMed
  146. Myerson JW, et al. 2021. Nat Nanotechnol. Online ahead of print. PubMed
  147. Jia Q, et al. 2021. Theranostics. 4699:11. PubMed
  148. Zhu H, et al. 2021. Cell Metabolism. :. PubMed
  149. Kuai Y, et al. 2020. Theranostics. 5.099305556. PubMed
  150. Michaud J, et al. 2017. BMC Microbiology . 10.1186/s12866-017-1036-0. PubMed
  151. Toomey CB, et al. 2018. Invest Ophthalmol Vis Sci. 59:662. PubMed
  152. Sun T, et al. 2017. Mucosal Immunol. 0.954861111. PubMed
  153. Liu W, et al. 2019. Epigenetics. 1.192361111. PubMed
  154. Kaur A, et al. 2019. Cancer Discov. 9:64. PubMed
  155. Bai B, et al. 2021. Theranostics. 11:6225. PubMed
  156. Huang Z, et al. 2021. Nat Commun. 12:145. PubMed
  157. Cho K, et al. 2021. iScience. 24:103117. PubMed
  158. Ma S, et al. 2022. Cell Rep. 38:110520. PubMed
  159. Sharma S, et al. 2021. Pathophysiology. 28:501. PubMed
  160. Nishida J, et al. 2022. STAR Protoc. 3:101306. PubMed
  161. McDonald B, et al. 2020. Cell Host Microbe. 28(5):660-668.e4. PubMed
  162. Devi S, et al. 2021. Immunity. 54(6):1219-1230.e7. PubMed
  163. Qin Q, et al. 2021. Cell Reports. 35(8):109161. PubMed
  164. Riedelberger M, et al. 2020. Bio Protoc. e3552:10. PubMed
  165. Min C, et al. 2020. Cell Death Dis. 0.847916667. PubMed
  166. Pundir P, et al. 2020. Cell Host & Microbe. 26(1):114-122. PubMed
  167. Simões FC, et al. 2020. Nat Commun. 0.875. PubMed
  168. Sendler M, et al. 2020. Gastroenterology. 158:253. PubMed
  169. Pagan JD, et al. 2018. Cell. 172:564. PubMed
  170. Li H, et al. 2022. Gut Microbes. 14:2127456. PubMed
  171. Li Y, et al. 2022. Front Cardiovasc Med. 9:830781. PubMed
  172. Sun S, et al. 2021. Front Immunol. 12:777665. PubMed
  173. Fields L, et al. 2021. Mol Ther. 29:2554. PubMed
  174. Jiang Y, et al. 2021. Cell Death Differ. 28:3009. PubMed
  175. Murr NJ, et al. 2021. Nutrients. 13:. PubMed
  176. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  177. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  178. Reimer E, et al. 2020. J Cell Sci. 134:00:00. PubMed
  179. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  180. Alonso-Herranz L, et al. 2020. Elife. 9:00. PubMed
  181. Pashover-Schallinger E, et al. 2012. FASEB J. 26:3891. PubMed
  182. Galle-Treger L, et al. 2019. Nat Commun. 10:713. PubMed
  183. Li B, et al. 2019. Oncol Rep. 41:608. PubMed
  184. Hu Y, et al. 2021. Cell Death Dis. 12:743. PubMed
  185. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  186. Kolodkin-Gal D, et al. 2021. Gut. Online ahead of print. PubMed
  187. Fu Y, et al. 2021. Front Cell Dev Biol. 9:689727. PubMed
  188. Andriessen EMMA, et al. 2021. EMBO Mol Med. 13:e11754. PubMed
  189. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  190. Han Y, et al. 2022. Int J Biol Sci. 18:5653. PubMed
  191. Gomez S, et al. 2022. J Immunother Cancer. 10:. PubMed
  192. Zhang S, et al. 2014. Eur J Pharmacol. 733:45. PubMed
  193. Kumagai S, et al. 2016. Cardiovasc Res. 109: 272 - 282. PubMed
  194. Ikezoe K, et al. 2016. Sci Rep. 6: 25781. PubMed
  195. Hasegawa T, et al. 2020. Sci Rep. 10:13480. PubMed
  196. Wang H, et al. 2020. Nat Mater. 1.655555556. PubMed
  197. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  198. Sun X, et al. 2020. Cell Metabolism. 31(1):189-206.e8.. PubMed
  199. Yu JM, et al. 2019. Nat Commun. 4.388888889. PubMed
  200. Nowak W, et al. 2020. EBioMedicine. 50:290-305.. PubMed
  201. Hightower RM, et al. 2019. Mol Ther. 28:189. PubMed
  202. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  203. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  204. Bitschar K, et al. 2019. Nat Commun. 10:2730. PubMed
  205. Lamb T, et al. 2022. Toxics. 10:. PubMed
  206. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  207. Song J, et al. 2021. Am J Physiol Heart Circ Physiol. 320:H323. PubMed
  208. Li ZL, et al. 2021. Mol Ther Nucleic Acids. 25:502. PubMed
  209. Tang Z, et al. 2021. Stem Cell Res Ther. 12:397. PubMed
  210. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  211. Morikawa M, et al. 2016. PLoS One. 11:e0163607. PubMed
  212. Yahuafai J, et al. 2014. J Control Release. 28:192. PubMed
  213. Sundar I, et al. 2017. Biochem Biophys Res Commun. 10.1016/j.bbrc.2017.09.157. PubMed
  214. Maniati E, et al. 2020. Cell Rep. 30:525. PubMed
  215. Han MS, et al. 2020. Proc Natl Acad Sci U S A. 117:2751. PubMed
  216. Doni A, et al. 2021. Nat Commun. 12:3739. PubMed
  217. Kang M, et al. 2021. Front Cell Dev Biol. 8:596622. PubMed
  218. He S, et al. 2021. Front Pharmacol. 12:743837. PubMed
  219. Wang S, et al. 2022. J Inflamm Res. 14:7107. PubMed
  220. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  221. Al-Barwani F, et al. 2014. PLoS One. 9:104523. PubMed
  222. Lieber S, et al. 2014. Mol Pharmacol. 87:162. PubMed
  223. Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
  224. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  225. Yang H, et al. 2020. Arterioscler Thromb Vasc Biol. 40:e350. PubMed
  226. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  227. Wang Y, et al. 2020. eLife. 9:e57438.. PubMed
  228. Chen M, et al. 2019. Cell Stem Cell. 25:501. PubMed
  229. Moufarrij S, et al. 2020. Sci Rep. 10:3470. PubMed
  230. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  231. William M, et al. 2018. J Immunol. 200:4102. PubMed
  232. Ayturk UM, et al. 2020. J Bone Miner Res. 35:1981. PubMed
  233. Huang T, et al. 2022. Nat Commun. 13:3489. PubMed
  234. Sun L, et al. 2022. Adv Sci (Weinh). 9:e2104051. PubMed
  235. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  236. Gao X, et al. 2021. Nature. 589:591. PubMed
  237. Lee SA, et al. 2021. Cells. 10:. PubMed
  238. Fan ZP, et al. 2021. Front Immunol. 12:743354. PubMed
  239. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  240. Valkenburg S, et al. 2016. Sci Rep. 6:22666. PubMed
  241. Asada S, et al. 2018. Nat Commun. 9:2733. PubMed
  242. Zhang J, et al. 2018. Oncoimmunology. 7:e1461301. PubMed
  243. Hayashida E, et al. 2019. J Neuroinflammation. 0.789583333. PubMed
  244. Wang S, et al. 2020. J Cell Mol Med. 24:722. PubMed
  245. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  246. Xu M, et al. 2020. Cell. 178(6):1478-1492.e20.. PubMed
  247. Wang Q, et al. 2020. Respir Res. 0.981944444. PubMed
  248. Sugita Y, et al. 2021. Oncol Rep. 45:. PubMed
  249. Zhang F, et al. 2021. J Immunol Res. 2021:5521051. PubMed
  250. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  251. Liu Q, et al. 2021. Adv Mater. 33:e2102852. PubMed
  252. Xiang Y, et al. 2014. Proc Natl Acad Sci U S A. . PubMed
  253. Erin N, et al. 2015. Brain Behav Immun. 48: 174-185. PubMed
  254. Peng X, et al. 2015. J Immunol. 195: 2797-2805. PubMed
  255. Tsunekuni K, et al. 2020. J Clin Med. 9:00. PubMed
  256. Huang WC, et al. 2020. Adv Mater. 32:e2005637. PubMed
  257. Hering L, et al. 2020. Front Immunol. 1.747222222. PubMed
  258. Silva-Cayetano A, et al. 2020. Med. 2(3):243-262.e8. PubMed
  259. Baker GJ, et al. 2020. Cell Syst. 0.647222222. PubMed
  260. Huang WC, et al. 2020. NPJ Vaccines. 5:23. PubMed
  261. Lee MC, et al. 2017. J Immunol. 198:3565. PubMed
  262. Perrotta C, et al. 2018. Front Immunol. 9:1186. PubMed
  263. Chen X, et al. 2021. Cell Death Dis. 12:1123. PubMed
  264. Zhu Y, et al. 2021. Int J Oral Sci. 13:25. PubMed
  265. Huang WC, et al. 2020. NPJ Vaccines. 5:23. PubMed
  266. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  267. Aguilera TA, et al. 2020. Clin Cancer Res. 26:2972. PubMed
  268. Nakayama Y, et al. 2020. Proc Natl Acad Sci U S A. 117:14365. PubMed
  269. Smith R, et al. 2016. J Leukoc Biol. 100:371-80. PubMed
  270. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  271. Zhang J, et al. 2014. J Immunol. 193:5149. PubMed
  272. Li Z et al. 2018. Immunity. 49(4):640-653 . PubMed
  273. Peltzer N, et al. 2018. Nature. 557:112. PubMed
  274. Hilt ZT, et al. 2019. JCI Insight. 4:5. PubMed
  275. Wang L, et al. 2020. J Nanobiotechnology. 18:38. PubMed
  276. Jiang M, et al. 2021. Front Pharmacol. 12:657486. PubMed
  277. Song HY, et al. 2021. Mol Ther. S1525-0016:00472-X. PubMed
  278. Luo ZW, et al. 2021. Int J Nanomedicine. 16:2949. PubMed
  279. Wang X, et al. 2021. Sci Transl Med. 13:. PubMed
  280. Shin SH, et al. 2022. Clin Exp Otorhinolaryngol. . PubMed
  281. Lau A, et al. 2022. Sci Adv. 8:eabm0142. PubMed
  282. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  283. Xiao M, et al. 2022. Mol Oncol. 16:1026. PubMed
  284. Petty AJ, et al. 2021. JCI Insight. 6:. PubMed
  285. Gawish R, et al. 2022. Elife. 11:. PubMed
  286. Jia J, et al. 2022. Nat Commun. 13:6804. PubMed
  287. Horwitz E, et al. 2014. Cancer Discovery. 4:730. PubMed
  288. Wang Y, et al. 2015. Sci Rep. 5:16973. PubMed
  289. Ang QY, et al. 2020. Cell. 181(6):1263-1275.e16. PubMed
  290. Wang X, et al. 2020. Immunity. 328:52. PubMed
  291. Liu Y, et al. 2019. Am J Physiol Cell Physiol. 317:C762. PubMed
  292. Samir P, et al. 2019. Nature. 573:590. PubMed
  293. Abe H, et al. 2019. Nat Commun. 10:2824. PubMed
  294. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  295. Han J, et al. 2022. Cell Discov. 8:122. PubMed
  296. Xu Z, et al. 2022. Cell Death Dis. 13:502. PubMed
  297. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
  298. Wu KKL, et al. 2021. Nat Commun. 12:6637. PubMed
  299. Witas R, et al. 2021. Int J Mol Sci. 22:. PubMed
  300. Feng L, et al. 2014. Biochem Pharmacol. 89:109. PubMed
RRID
AB_893498 (BioLegend Cat. No. 123109)
AB_893486 (BioLegend Cat. No. 123110)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
UniProt
View information about F4/80 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 10/25/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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