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PE anti-human NKp80 Antibody

Pricing & Availability
Clone
5D12 (See other available formats)
Regulatory Status
RUO
Other Names
KLRF1, killer cell lectin-like receptor subfamily F, member 1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
A_5D12_PE_011310
Human peripheral blood lymphocytes stained with CD56 (HCD56) APC and 5D12 PE (top) or mouse IgG1, κ PE isotype control (bottom).
  • A_5D12_PE_011310
    Human peripheral blood lymphocytes stained with CD56 (HCD56) APC and 5D12 PE (top) or mouse IgG1, κ PE isotype control (bottom).
  • B_5D12_PE_011310
Compare all formats See PE spectral data
Cat # Size Price Save
346706 100 tests ¥64,680
Description

NKp80, also known as killer cell lectin-like receptor subfamily F, member 1 (KLRF1), is a type II transmembrane C-type lectin-like receptor. NKp80 is expressed on the cell surface of nearly all NK cells as a homodimer with approximately 80 kD molecular mass. It is also found on a subset of effector memory CD8 T cells and γ/δ T cells. NKp80 induces NK-cell mediated cytotoxicity and cytokine production through interaction with its ligand, AICL (activation-induced C-type lectin), which is selectively expressed on myeloid cells.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant ectodomain of human NKp80
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Welte S, et al. 2006. Nat. Immunol. 7:1334.
  2. Kuttruff S, et al. 2009. Blood 113:358.
Product Citations
  1. Loyon R, et al. 2016. J Immunol. 197: 85 - 96. PubMed
  2. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  3. Manser AR, et al. 2019. J Immunol. 203:2301. PubMed
  4. Yang C, et al. 2019. Nat Commun. 10:3931. PubMed
RRID
AB_1967147 (BioLegend Cat. No. 346706)

Antigen Details

Structure
Type II transmembrane c-type lectin-like receptor, homodimer, 80 kD
Distribution

NK cells, subset of CD8 T and γ/δ T cells

Ligand/Receptor
AICL (activation-induced C-type letcin)
Bioactivity
induce NK cell-mediated cytolysis and cytokine release
Cell Type
NK cells, T cells
Biology Area
Costimulatory Molecules, Immunology, Innate Immunity
Antigen References

1. Kuttruff S, et al. 2009. Blood 113:358
2. Vitale M, et al. 2001. Eur. J. Immunol. 31:233

Gene ID
51348 View all products for this Gene ID
UniProt
View information about NKp80 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 08/23/2022

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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