PE anti-human LAP (TGF-β1) Antibody

Pricing & Availability
TW4-2F8 (See other available formats)
Other Names
Latency Associated Peptide (LAP), Transforming growth factor beta 1 (TGF-b1), TGFB1, DPD1
Mouse IgG1, κ
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Product Citations
Human peripheral blood mononuclear cells stimulated with CD3 (UCHT1), CD28 (CD28.2), and recombinant human IL-2 for 24-hours; and then surface stained with TW4-2F8 PE (top) or mouse IgG1, κ PE isotype control (bottom), followed by intracelluar staining with FOXP3 (259D) Alexa Fluor® 647 (gated on CD4+ lymphocytes)
  • TW4-2F8_PE_1_082610
    Human peripheral blood mononuclear cells stimulated with CD3 (UCHT1), CD28 (CD28.2), and recombinant human IL-2 for 24-hours; and then surface stained with TW4-2F8 PE (top) or mouse IgG1, κ PE isotype control (bottom), followed by intracelluar staining with FOXP3 (259D) Alexa Fluor® 647 (gated on CD4+ lymphocytes)
  • TW4-2F8_PE_2_082610
See PE spectral data
Cat # Size Price Save
349603 25 tests ¥24,000
349604 100 tests ¥59,000
This product is scheduled for discontinuation. Please use the availability checker to determine current availability.

TGF-β1 (transforming growth factor β1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-β. TGF-β is synthesized as a large protein precursor and then secreted as a complex of TGF-β and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-β to prevent its activity.  TGF-β requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-β binds to the integrins αvβ1, αvβ6, αvβ8, and α8β1 through RGD domain. TGF-β plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-β is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A recent study has shown that LAP is an activated Treg surface marker.

Product Details
Technical data sheet

Product Details

Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Chen D, et al. 2018. Nat Commun. 9:873. PubMed
  2. Tankou SK, et al. 2018. Ann Neurol. 83:1147. PubMed
  3. Toor SM, et al. 2018. Clin Exp Immunol. 191:189. PubMed
  4. Bedke T, et al. 2014. Immunol Cell Biol. . PubMed
AB_10645477 (BioLegend Cat. No. 349603)
AB_10645520 (BioLegend Cat. No. 349604)

Antigen Details

About 400 amino acids, N-terminal signal peptide is required for secretion from a cell, a pro-region (LAP) and C-terminal region that becomes the mature TGF-β molecule following its release from the pro-region by proteolytic cleavage.

Ubiquitously expressed by many kinds of cells

Multifunctional cytokine, regulates cells proliferation, and differentiation
TGF-βRI, -RII, -RIII, CD105, LTBP, integrins
Cell Type
B cells, Dendritic cells, Tregs
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroinflammation, Neuroscience, Signal Transduction
Molecular Family
Cytokines/Chemokines, Growth Factors
Antigen References

1. Yi JJ, et al. 2010. Cell 142:144.
2. Tran DQ, et al. 2009. Blood 113:5125.
3. Lu M, et al. 2002. J. Cell. Sci. 115:4641.
4. Khalil N. 1999. Microbes Infect. 1:1255.

Gene ID
7040 View all products for this Gene ID
View information about LAP on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 03/23/2016

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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