PE anti-human CD172g (SIRPγ) Antibody

Pricing & Availability
Clone
LSB2.20 (See other available formats)
Regulatory Status
RUO
Other Names
SIRPgamma, Signal regulatory protein β2 (SIRPβ2)
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
LSB2dot20_PE_102108.jpg
Human peripheral blood lymphocytes stained with LSB2.20 PE
  • LSB2dot20_PE_102108.jpg
    Human peripheral blood lymphocytes stained with LSB2.20 PE
See PE spectral data
Cat # Size Price Save
336606 100 tests ¥48,000
Description

Signal Regulatory Proteins (SIRPs) comprise a family of several transmembrane glycoproteins (SIRPα, SIRPβ, and SIRPγ) that belong to immunoglobulin superfamily. SIRPγ is also known as CD172g or SIRPβ2 which is primarily expressed on T cells and a subpopulation of B cells. Like CD172a, the ligand of CD172g is CD47. But the binding affinity with CD172g is lower than CD172a. The biological functions of CD172g include regulation of T-cell transendothelial migration and induction of T cell apoptosis.

Product Details
Technical data sheet

Product Details

Reactivity
Human, African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications include: blocks T-cell transendothelial migration

Application References

(PubMed link indicates BioLegend citation)
  1. Stefanidakis M, et al. 2008. Blood 112:1280
Product Citations
  1. Sim J, et al. 2019. MAbs. 11:1036. PubMed
  2. Cella M, et al. 2019. Nat Immunol. 1.513888889. PubMed
RRID
AB_1227766 (BioLegend Cat. No. 336606)

Antigen Details

Structure
Transmembrane glycoprotein, Ig superfamily
Distribution

T cells, B cell subset

Function
Regulate T-cell transendothelial migration, induce T cell apoptosis
Ligand/Receptor
CD47
Cell Type
B cells, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers
2. Brooke G, et al. 2004. J. Immunol. 173:2562

Gene ID
55423 View all products for this Gene ID
UniProt
View information about CD172g on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 10/25/2016

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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