PE anti-human CD143 (Angiotensin-converting enzyme) Antibody

Pricing & Availability
5-369 (See other available formats)
Other Names
ACE, kininase II, dipeptidyl dipeptidase 1, peptidase P, carboxycathepsin
Mouse IgG1, κ
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GM-CSF-stimulated human peripheral blood mononuclear cells (day-3) were stained with CD143 (clone 5-369) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram). Data shown was gated on CD14+ cell population
  • 5-369_PE_CD143_Antibody_101518
    GM-CSF-stimulated human peripheral blood mononuclear cells (day-3) were stained with CD143 (clone 5-369) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram). Data shown was gated on CD14+ cell population
See PE spectral data
Cat # Size Price Save
344204 100 tests ¥52,000

CD143 (ACE, kininase II, peptidyl dipeptidase 1, peptidase P, carboxycathepsin) is a 171 kD, type I, single chain transmembranal metallopeptidase, whose cofactor is zinc. Its main targets are angiotensin I and bradykinin, acting as a blood pressure regulator. CD143 is expressed in endothelial cells; varying amounts of CD143 have been reported in different epithelial cells. The activation of macrophages and histiocytes induces the expression of this molecule.

Product Details
Technical data sheet

Product Details

Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2222985 (BioLegend Cat. No. 344204)

Antigen Details

Single chain, type I transmembranal zinc metallopeptidase, 170 kD.

Endothelial cells, some types of epithelial cells, activated macrophages and histiocytes.

Regulates blood pressure by promoting vasoconstriction by the conversion of angiotensin I to angiotensin II and by the degradation of bradykinin, a vasodilator.
Angiotensin I, bradykinin.
Blood pressure regulator.
Cell Type
Endothelial cells, Epithelial cells, Macrophages
Biology Area
Molecular Family
CD Molecules
Antigen References

1. Nakamura T, et al. 2009. Int Heart J. 50:501.
2. Jayasooriya AP, et al. 2008. P. Natl. Acad. Sci. USA 105:6531.
3. Jokubaitis VJ, et al. 2008. Blood 111:4055.
4. Arndt PG, et al. 2006. J. Immunol. 177:7233.
5. Balyasnikova IV, et al. 2002. Biochem J. 362:585.

Gene ID
1636 View all products for this Gene ID
View information about CD143 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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