- GB11 (See other available formats)
- Regulatory Status
- Other Names
- Granzyme-2, serine protease B, CCP1, Asp-ase, CTLA-1
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
Granzyme B is a 32 kD serine protease, also known as granzyme-2, serine protease B, CCP1, Asp-ase, and CTLA-1. Granzyme B is abundantly stored in the granules of cytotoxic T lymphocytes and NK cells. Low level of expression has been reported in granulocytes, B cells, and activated dendritic cells. Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor.Product Details
- Verified Reactivity
- Human, Mouse
- Reported Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Pacific Blue™ under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Violet Laser (405 nm)
(PubMed link indicates BioLegend citation)
- Wever PC, et al. 1998. Immunology. 93:383
- Arens R, et al. 2004. J. Exp. Med. 199:1595
- Lima M, et al. 2003. Am. J. Pathol. 163:763
- Wiede F, et al. 2014. J Autoimmun. 53:105. PubMed
- Baker GF, et al. 2014. Cancer Res. 74:5079. PubMed
- Nacer A, et al. 2014. PLoS Pathog. 10:1004528. PubMed
- Sharma SK, et al. 2015. J Immunol. 194:5529. PubMed
- Product Citations
AB_2562195 (BioLegend Cat. No. 515407)
AB_2562196 (BioLegend Cat. No. 515408)
- 32 kD serine protease
Cytotoxic T-cells and NK cells, low on granulocytes, B cells and activated dendritic cells
- Induction of cell death and apoptosis
- Mannose-6-phosphate receptor
- Cell Type
- B cells, Dendritic cells, NK cells, T cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience
- Molecular Family
- Enzymes and Regulators, Proteases
- Antigen References
1. Estebanez-Perpina E, et al. 2000. Biol Chem. 381:1203
2. Griffiths GM. And S. Isaaz, et al. 1993. J. Cell Biol. 120:885
3. Spaeny-Dekking EH, et al. 1998. J. Immunol. 160:3610
4. Wagner C, et al. 2008. Mol. Immunol. 45:1761
- Gene ID
- 3002 View all products for this Gene ID 14939 View all products for this Gene ID 171528 View all products for this Gene ID
- View information about granzyme b on UniProt.org
|FITC anti-human/mouse Granzyme B||GB11||ICFC|
|Alexa Fluor® 647 anti-human/mouse Granzyme B||GB11||ICFC|
|Pacific Blue™ anti-human/mouse Granzyme B||GB11||ICFC|
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