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APC anti-mouse CD38 Antibody

Pricing & Availability
Clone
90 (See other available formats)
Regulatory Status
RUO
Other Names
T10
Isotype
Rat IgG2a, κ
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Product Citations
publications
90_APC_080607
C57BL/6 mouse splenocytes stained with 90 APC
  • 90_APC_080607
    C57BL/6 mouse splenocytes stained with 90 APC
Compare all formats See APC spectral data
Cat # Size Price Save
102711 25 µg ¥18,480
102712 100 µg ¥61,320
Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow pre-B cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Ouchida R, et al. 2012. Proc Natl Acad Sci U S A. 109:e2699. PubMed
  2. Vijayan K, et al. 2021. Cell Reports. 36(5):109489. PubMed
  3. Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed
  4. Pérez‐Mazliah D et al. 2017. EBioMedicine. 24:216-230 . PubMed
  5. Xu S, et al. 2012. Blood. 119:767. PubMed
  6. Wilder BK, et al. 2022. NPJ Vaccines. 7:58. PubMed
  7. Onodera T, et al. 2016. J Immunol. 196: 4172 - 4184. PubMed
  8. Schoeler K, et al. 2019. FEBS J. 10.1111/febs.14934. PubMed
  9. Matsumoto K, et al. 2017. PLoS One. 12(6):e0175406. PubMed
  10. Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed
  11. Cavelier C, et al. 2009. Cancer Res. 69:8652. PubMed
  12. Lu X, et al. 2019. Cell Rep. 28:472. PubMed
  13. Lazarian G, et al. 2021. Cancer Cell. 39(3):380-393.e8. PubMed
  14. Kim H, et al. 2011. Exp Hematol. 39:741. PubMed
  15. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  16. Li X, et al. 2018. Immunity. 48:530. PubMed
  17. Li X, et al. 2021. Front Oncol. 11:703087. PubMed
  18. Platteel ACM, et al. 2018. Front Immunol. 1.544444444. PubMed
  19. Mesin L, et al. 2020. Cell. 180(1):92-106.e11.. PubMed
RRID
AB_312932 (BioLegend Cat. No. 102711)
AB_312933 (BioLegend Cat. No. 102712)

Antigen Details

Structure
ADP-ribosyl hydrolase, 42 kD
Distribution

B cells, NK cells, T cell subset, brain, muscle, kidney

Function
Regulation of cellular activation/proliferation, adhesion, metabolism of cADPR and NAADP
Ligand/Receptor
CD31, hyaluronic acid
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Shubinsky G, et al. 1997. Immunity 7:315.
3. Cesano A, et al. 1998. J. Immunol. 160:1106.
4. Cockayne DA, et al. 1998. Blood 92:1324.

Gene ID
12494 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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