- 15C4 (See other available formats)
- Regulatory Status
- Other Names
- OLR1, LOX1, LOXIN, SLOX1, CLEC8A, SCARE1
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
Lectin-like oxidized LDL receptor 1 (LOX-1) also known as CLEC8A is a 31 kD single pass type II transmembrane protein and member of the C-type lectin superfamily. LOX-1 is a scavenger receptor and is involved in endocytosis, phagocytosis and cytokine production. CLEC8A is expressed by endothelial cells, smooth muscle cells, platelets, fibroblasts, macrophages, and is upregulated by inflammatory and oxidative stimuli. LOX-1 recognizes numerous ligands including lipoproteins, apoptotic cells heat shock proteins, C-reactive protein and oxidized LDL. LOX-1 is implicated in atherosclerosis and vascular inflammation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- LOX-1 ectodomain: Fc fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescent staining of acetone-fixed frozen human skin sections1.
(PubMed link indicates BioLegend citation)
- Li D, et al. 2012. J. Exp. Med. 209:109. (IHC)
- Product Citations
AB_2563472 (BioLegend Cat. No. 358605)
AB_2563473 (BioLegend Cat. No. 358606)
- Single pass, type II, transmembrane protein, 31 kD, homodimer, member of the C-type lectin superfamily.
- Endothelial cells, smooth muscle, platelets, fibroblasts, macrophages; Upregulated by inflammatory and oxidative stimuli
- Scavenger receptor, involved in endocytosis, phagocytosis and cytokine production
- Recognizes numerous ligands including lipoproteins, apoptotic cells, heat shock proteins, C-reactive protein, oxidized LDL
- Cell Type
- Endothelial cells, Platelets, Fibroblasts, Macrophages, Dendritic cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Adhesion Molecules
- Antigen References
1. Yin Y, et al. 2013. Eur. J. Cell Biol. 92:150.
2. Khaidakov M. and Mehta JL. 2012. PLoS One. 7:e46973.
3. Sawamura T, et al. 2012. Curr. Opin. Lipidol. 23:439.
4. Lin FY, et al. 2011. J. Immunol. 186:4405.
5. Parlato S, et al. 2010. Blood 115:1554.
- Gene ID
- 4973 View all products for this Gene ID
- View information about LOX-1 on UniProt.org
|PE anti-human LOX-1||15C4||FC|
|Purified anti-human LOX-1||15C4||FC, IHC-F|
|APC anti-human LOX-1||15C4||FC|
|Brilliant Violet 421™ anti-human LOX-1||15C4||FC|
|TotalSeq™-A0591 anti-human LOX-1||15C4||PG|
|TotalSeq™-C0591 anti-human LOX-1||15C4||PG|
|TotalSeq™-B0591 anti-human LOX-1 Antibody||15C4||PG|
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