- QA19A16 (See other available formats)
- Regulatory Status
- Other Names
- GHI/61, M130, RM3/1, p155, Hemoglobin/Haptoglobin Complex Receptor, macrophage-associated antigen, ED2(rat)
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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AB_2922574 (BioLegend Cat. No. 364303)
AB_2922574 (BioLegend Cat. No. 364304)
- 134 kD (non-reduced)/155 kD (reduced) glycoprotein, scavenger receptor superfamily
Monocytes, macrophages, Kuffer cells, subset of dendritic cells, subset of hematopoietic stem/progenitor cells
- Clearance of haptoglobin-hemoglobin complex, regulation of cytokine production by macrophages
- Haptoglobin-hemoglobin complex, TWEAK
- Antigen References
- Roth J, et al. 1994. Transolantation. 57:127
- Van den Heuvel MM, et al.1999. J Leukoc Biol. 66:858
- Sulahian TH, et al. 2000. Cytokines. 12:1312
- Fabriek BO, et al. 2007. J Neuroimmunol. 187:179
- Gene ID
- 9332 View all products for this Gene ID
- View information about CD163 on UniProt.org
|Purified anti-human CD163 Recombinant Antibody||QA19A16||FC, IHC-P|
|Alexa Fluor® 594 anti-human CD163 Recombinant||QA19A16||IHC-P|
|Alexa Flour® 647 anti-human CD163 Recombinant Antibody||QA19A16||FC, IHC-P|
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