- W18070C (See other available formats)
- Regulatory Status
- Other Names
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
CD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+ thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+ cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Human CD161 transfected cell line
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
AB_2910381 (BioLegend Cat. No. 307507)
AB_2910381 (BioLegend Cat. No. 307508)
- Type II glycoprotein, 40-44 kD homodimer, C-type lectin superfamily
NK cells, T subset, subset of CD3+ thymocytes
- LLT-1 (Lectin-like transcript-1)
- Antigen References
- Takahashi T, et al. 2006. J Immunol. 176:211-6.
- Cosmi L, et al. 2008. J Exp Med. 205:1903-16.
- Aldemir H, et al. 2005. J Immunol. 175:7791-5.
- Rosen DB, et al. 2008. J Immunol. 180:6508-17.
- Gene ID
- 3820 View all products for this Gene ID
- View information about CD161 on UniProt.org
|PE anti-human CD161||W18070C||FC|
|Purified anti-human CD161||W18070C||FC|
|Alexa Fluor® 647 anti-human CD161||W18070C||FC|
|PE/Cyanine7 anti-human CD161||W18070C||FC|
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