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Purified anti-Tubulin β 3 (TUBB3) Antibody (Previously Covance catalog# MMS-435P)

Pricing & Availability
Clone
TUJ1 (See other available formats)
Regulatory Status
RUO
Other Names
CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, Tubulin beta-3 chain, tubulin beta-III, tubulin beta-4 chain, class III beta-tubulin
Previously
Covance Catalog# MMS-435P
Isotype
Mouse IgG2a, κ
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Product Citations
publications
A_TUJ1_PURE_Tubulin-beta3_IHCP_Hu_011618
IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • A_TUJ1_PURE_Tubulin-beta3_IHCP_Hu_011618
    IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • B_TUJ1_PURE_Tubulin-beta3_IHCP_Rat_011618
    IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded rat brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • C_TUJ1_PURE_Tubulin-beta3_WB_011618
    Western blot of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of Mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blots were incubated with 1 ug/mL of TUJ1 or mouse IgG overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • D_TUJ1_PURE_Tubulin-beta3_ICC_011618
    ICC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on SH-SY5Y neuroblastoma cells. The cells were fixed by 4% PFA, permeabilized with a buffer containing 0.1% Triton X-100 and 0.25% BSA, and blocked with 2% Normal Goat Serum and 0.02% BSA. The cells were then incubated with 1 µg/mL of the primary antibody for 3 hours at room temperature, followed by incubation with 0.5 µg/mL Alexa Fluor® 594 goat anti-mouse IgG (Cat. No. 405326) for 1 hour at room temperature. Nuclei were counterstained with DAPI. The image was captured with a 60X objective Scale bar: 20 µm
  • E_Ankita_Patil
    Methanol fixed superior cervical ganglion neurons were stained with anti-tubulin β3 (pink) and anti-TRIM46 (aqua), then stained with secondary antibodies, phalloidin (orange) and DAPI (blue). Image generously submitted to the 2017 Cell Life Imaging Competition by Ankita Patil from Drexel University.
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Cat # Size Price Save
801213 25 µL ¥23,320
801201 100 µL ¥58,300
801202 250 µL ¥86,020
Description

Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This antibody was raised against microtubules derived from rat brain.
Formulation
Phosphate-buffered solution + 0.03% Thimerosal.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1.0 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

IHC-P - Quality tested
WB, ICC - Verified
FC - Reported in the literature, not verified in house
SB - Community verified
Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: flow cytometry4, immunofluorescence microscopy1-5,7, immunohistochemistry5,7, Western blotting8, and spatial biology (IBEX)9,10.

This antibody is well characterized and highly reactive to neuron specific Class III ß-tubulin (ßIII). TUJ1 does not identify ß-tubulin found in glial cells. TUJ1 recognizes an epitope located within the last 15 C-terminal residues8.

Additional Product Notes

This product has been verified for IHC-F (Immunohistochemistry - frozen tissue sections) on the NanoString GeoMx® Digital Spatial Profiler. The GeoMx® enables researchers to perform spatial analysis of protein and RNA targets in FFPE and fresh frozen human and mouse samples. For more information about our spatial biology products and the GeoMx® platform, please visit our spatial biology page.

Application References

(PubMed link indicates BioLegend citation)
  1. Nishimura K, et al. 2017. PLoS One. 12(1): e0170568. (ICC)
  2. Jongbloets J, et al. 2017. Nat Commun. 8: 14666. (ICC) PubMed
  3. Liu W.J, et al. 2015. Eur J Histochem. 59(1): 2464. (ICC) PubMed
  4. Chintalapudi SR, et al. 2016. Front Aging Neursci. 8:93. (FC, ICC) PubMed
  5. Ambasudhan R, et al. 2011. Cell Stem Cell. 9(2):113. (IHC, ICC)
  6. Hu X., et al. 2006. Nature Neuroscicene. 9(12):1520. (WB) PubMed
  7. Zechner D., et al. 2003. Develop Biology. 258(2):406. (ICC, IHC)
  8. Lee MK, et al. 1990. Proc. Natl. Acad. Sci. USA 18:7195. (WB)
  9. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  10. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Boyer NP, et al. 2018. Eneuro. 55:1847. PubMed
  2. Lee SW et al. 2018. Developmental cell. 46(1):73-84 . PubMed
  3. Chia PH et al. 2018. eLife. 7 pii: e32451. PubMed
  4. Erwig MS, et al. 2019. Elife. 8:. PubMed
  5. Tohgi N, et al. 2017. Cell Cycle. 16:95. PubMed
  6. Nicole O, et al. 2018. Mol Psychiatry. 23:2209. PubMed
  7. Kirihara T, et al. 2019. iScience. 14:301. PubMed
  8. Sanli I, et al. 2018. Cell Rep. 23:337. PubMed
  9. Croteau LP, et al. 2019. Sci Rep. 9:12009. PubMed
  10. Ioannou MS et al. 2019. Cell. 177(6):1522-1535 . PubMed
  11. Paonessa F et al. 2019. Cell reports. 26(3):582-593 . PubMed
  12. de la Cerda B et al. 2019. Stem cell research. 1726:26:00 . PubMed
  13. García‐Peña CM et al. 2018. Frontiers in neuroanatomy. 0.566666667 . PubMed
  14. Coleman JH, et al. 2017. J Comp Neurol. 525:3391. PubMed
  15. Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed
  16. Huang YA et al. 2017. Cell. 168(3):427-441 . PubMed
  17. Hegarty DM, et al. 2018. Pain Rep. 3:e664. PubMed
  18. Dai WJ, et al. 2019. Evid Based Complement Alternat Med. 2019:8413576. PubMed
  19. Wang XW, et al. 2020. Cell Rep. 31:107537. PubMed
  20. Woeste MA, et al. 2019. J Biol Chem. 294:3853. PubMed
  21. Tian R, et al. 2019. Neuron. 104:239. PubMed
  22. Birsa N, et al. 2021. Sci Adv. 7: . PubMed
  23. Castelli LM, et al. 2021. Mol Neurodegener. 16:53. PubMed
  24. Nakayama T, et al. 2021. Cell Rep Med. 2:100421. PubMed
  25. Ye M, et al. 2021. Cell Death Dis. 12:1149. PubMed
  26. Seebauer L, et al. 2022. Int J Mol Sci. 23:. PubMed
  27. Zainul Z, et al. 2022. Sci Rep. 12:3344. PubMed
  28. Ahangari N, et al. 2021. J Neuropathol Exp Neurol. 80:944. PubMed
  29. Dang LT, et al. 2021. Dev Neurobiol. 81:696. PubMed
  30. Tsefou E, et al. 2021. Biochem J. 478:4099. PubMed
  31. Jacquier A, et al. 2022. Acta Neuropathol. 144:707. PubMed
  32. Wang Z, et al. 2022. Research (Wash D C). 2022:9832128. PubMed
  33. Schroeter MS, et al. 2022. MRS Bull. 47:530. PubMed
  34. Lee J, et al. 2022. Nat Protoc. 17:1266. PubMed
  35. Gai M, et al. 2016. EMBO Rep. 17: 1396 - 1409. PubMed
  36. Nonomura K, et al. 2016. Nature. 541:176-181. PubMed
  37. Ueki J, et al. 2017. Sci Rep. 7:42522. PubMed
  38. Fernandes HJR, et al. 2020. Cell Rep. 33:108263. PubMed
  39. Ko KW, et al. 2020. J Cell Biol. 219:00:00. PubMed
  40. Tilak M, et al. 2021. Molecular Cancer Research. 19(5):757-770. PubMed
  41. Alonso-Barroso E, et al. 2017. Stem Cell Research. 23:173-177. PubMed
  42. Wang YL, et al. 2021. Cell Reports. 36(8):109537. PubMed
  43. Tristan CA, et al. 2020. bioRxiv. . PubMed
  44. Abey A, et al. 2020. Brain Pathol. 31:144. PubMed
  45. Orozco-Díaz R, et al. 2019. PLoS One. 14:e0220393. PubMed
  46. Arber C, et al. 2019. Brain Commun. 1:fcz024. PubMed
  47. Valès S, et al. 2019. EBioMedicine. 49:172. PubMed
  48. Teissier A, et al. 2019. Mol Psychiatry. :. PubMed
  49. Macova I, et al. 2019. J Neurosci. 39:984. PubMed
  50. Inoue SI, et al. 2017. Hum Mol Genet. 26:4715. PubMed
  51. Shepherd DJ et al. 2017. Journal of neuropathology and experimental neurology. 76(8):683-696 . PubMed
  52. Kow Essuman et al. 2017. Neuron. 93(6):1334-1343 . PubMed
  53. Mangold CA et al. 2018. J Neurochem. 144(6):723-735 . PubMed
  54. Levin E et al. 2019. Cell reports. 26(4):1021-1032 . PubMed
  55. Murcia-Belmonte V, et al. 2019. Curr Biol. 29:1149. PubMed
  56. Daoutsali E et al. 2019. Stem Cell Res. 1723:19:00 . PubMed
  57. Ogawa Y et al. 2019. Neurosci Res. pii: S0168-0102(19)30120-8 . PubMed
  58. Tiethof AK, et al. 2018. Toxics. 6:52. PubMed
  59. Boso D, et al. 2019. Theranostics. 9:4860. PubMed
  60. Cha HL, et al. 2019. Mol Brain. 12:57. PubMed
  61. Wang G et al. 2019. eLife. 8 pii: e38730. PubMed
  62. Vinci M, et al. 2018. Nat Med. 24:1204. PubMed
  63. Laussu J, et al. 2017. Neural Dev. 12:10. PubMed
  64. Hu X, et al. 2019. Stem Cell Reports. 12:290. PubMed
  65. Valadas JS et al. 2018. Neuron. 98(6):1155-1169 . PubMed
  66. Ziller MJ, et al. 2018. Cell Stem Cell. 1.304861111. PubMed
  67. Park SY, et al. 2018. Mol Brain. 169:91. PubMed
  68. Babetto E, et al. 2020. Nat Neurosci. 23:1215. PubMed
  69. Eltahir MK, et al. 2022. PLoS One. 17:e0269683. PubMed
  70. Simoes S, et al. 2021. Cell Rep. 37:110182. PubMed
  71. Viais R, et al. 2021. Elife. 10:. PubMed
  72. Lafarga V, et al. 2021. EMBO J. 40:e103311. PubMed
  73. Kim S, et al. 2021. Nat Commun. 12:1807. PubMed
  74. Brown AL, et al. 2022. Nature. 603:131. PubMed
  75. Ruden JB, et al. 2021. Front Mol Neurosci. 14:777049. PubMed
  76. Tseng JH, et al. 2021. Cell Rep. 35:109037. PubMed
  77. Guo B, et al. 2021. Front Cell Dev Biol. 9:768970. PubMed
  78. Li F, et al. 2021. Nat Commun. 12:3845. PubMed
  79. Xia F, et al. 2021. Acta Neuropathol Commun. 51:9. PubMed
  80. Shin BC, et al. 2021. Experimental Neurology. 338:113603. PubMed
  81. Wang D, et al. 2020. Journal of Biological Chemistry. 295(25):8374-8386. PubMed
  82. Khoa LTP, et al. 2020. Cell Stem Cell. 27(3):441-458.e10. PubMed
  83. Domènech EB, et al. 2020. Invest Ophthalmol Vis Sci. 61:14:00. PubMed
  84. Elhardt C, et al. 2020. Transl Vis Sci Technol. 9:06. PubMed
  85. Lee SE, et al. 2020. Cell Death Dis. 1.19375. PubMed
  86. Coste C, et al. 2017. PLoS One. 10.1371/journal.pone.0177962. PubMed
  87. Miranda AM, et al. 2018. Nat Commun. 9:291. PubMed
  88. Liu C, et al. 2018. Stem Cell Reports. 4:43. PubMed
  89. Lee SY et al. 2018. Stem cell research. 30:145-149 . PubMed
  90. Vitali I et al. 2018. Cell. 174(5):1264-1276 . PubMed
  91. Roselló-Busquets C, et al. 2019. Front Cell Neurosci. 13:40. PubMed
  92. Stepp MA, et al. 2018. Int J Mol Sci. 19:12. PubMed
  93. Miltner AM, et al. 2019. Int J Mol Sci. 20. PubMed
  94. Canali G, et al. 2018. Hum Mol Genet. 27:1941. PubMed
  95. Haverfield JT, et al. 2017. Reprod Fertil Dev. 29:609. PubMed
  96. Arellano‐Viera E et al. 2019. Stem cell research. 1726:10:00 . PubMed
  97. Ribic A et al. 2019. Cell reports. 26(2):381-393 . PubMed
  98. Varga E et al. 2017. Stem cell research. 25:30-33 . PubMed
  99. Nguyen HX et al. 2014. The Journal of comparative neurology. 522(12):2767-83 . PubMed
  100. Bonnefont J, et al. 2019. Neuron. 103:1096. PubMed
  101. Giandomenico SL, et al. 2019. Nat Neurosci. 22:669. PubMed
  102. Stratton JA, et al. 2020. Front Aging Neurosci. 0.620833333. PubMed
  103. Yun T, et al. 2021. Cell Death Discov. 7:257. PubMed
  104. Herbst WA, et al. 2021. J Cell Biol. 220:. PubMed
  105. Heinrich A, et al. 2021. Cell Rep. 37:109885. PubMed
  106. Earley AM, et al. 2021. Sci Rep. 11:22257. PubMed
  107. Ramirez S, et al. 2021. STAR Protoc. 2:100987. PubMed
  108. Valenzuela M, et al. 2022. Stem Cell Res Ther. 13:261. PubMed
  109. Richardson RT, et al. 2021. Sci Rep. 11:11229. PubMed
  110. Guo X, et al. 2021. Cell. 184:4299. PubMed
  111. Vilallongue N, et al. 2022. Nat Commun. 13:6040. PubMed
  112. Kishi N, et al. 2016. Nat Commun. 7:10520. PubMed
  113. Nawaz M, et al. 2016. PLoS One. 11: 0148634. PubMed
  114. Tao W, et al. 2020. EMBO Mol Med. 12:e12291. PubMed
  115. Bae B, et al. 2020. RNA. 26:1414. PubMed
  116. Halikere A, et al. 2020. Mol Psychiatry. 25:1406. PubMed
  117. Song JM, et al. 2021. The Journal of Neuroscience. 41(11):2344-2359. PubMed
  118. Benito-Kwiecinski S, et al. 2021. Cell. 184(8):2084-2102.e19. PubMed
  119. Bayerl J, et al. 2021. Cell Stem Cell. . PubMed
  120. Eriksen AZ, et al. 2021. Cell Stem Cell. 28(7):1205-1220.e7. PubMed
  121. Elsayed AK, et al. 2021. Stem Cell Research. 54:102433. PubMed
  122. Lpez-Mrquez A, et al. 2019. Stem Cell Research. 38:101469. PubMed
  123. Sood S, et al. 2020. Proc Natl Acad Sci U S A. 22331:117. PubMed
  124. Lim SH, et al. 2020. J Cell Sci. :133. PubMed
  125. Savino E, et al. 2020. Cell Death Dis. 1.052777778. PubMed
  126. Saito K, et al. 2019. Cell Rep. 29:1555. PubMed
  127. Lilian SJ, et al. 2019. J Assoc Res Otolaryngol. 20:133. PubMed
  128. Milbreta U, et al. 2019. Mol Ther. 27:411. PubMed
  129. Arai Y, et al. 2019. Cell Rep. 29:645. PubMed
  130. Bucan V, et al. 2019. Int J Mol Med. 43:593. PubMed
  131. Petkovich DA et al. 2017. Cell metabolism. 25(4):954-960 . PubMed
  132. Auboyer L et al. 2019. Stem Cell Res. 1727:38:00 . PubMed
  133. Tomassoni–Ardori F, et al. 2019. Elife. 8:e46677. PubMed
  134. Van Der Raadt J, et al. 2019. Nucleic Acids Res. 47:5587. PubMed
  135. Raspa A, et al. 2019. CNS Neurosci Ther. 25:86. PubMed
  136. González C, et al. 2018. Mol Psychiatry. 23:2363. PubMed
  137. Liu H, et al. 2019. Front Cell Neurosci. 13:60. PubMed
  138. Mura M et al. 2018. Stem cell research. 29:170-173 . PubMed
  139. Hermanto Y et al. 2018. Journal of neuroscience research. 96(5):863-874 . PubMed
  140. Playne R, et al. 2018. J Stem Cells Regen Med. 7:e36998. PubMed
  141. Allende ML, et al. 2018. J Lipid Res. 59:550. PubMed
  142. Masumoto K, et al. 2022. Sci Rep. 12:10351. PubMed
  143. McClellan S, et al. 2021. Invest Ophthalmol Vis Sci. 62:14. PubMed
  144. Hagihara H, et al. 2021. Cell Rep. 37:109820. PubMed
  145. Boussaad I, et al. 2021. Sci Rep. 11:1439. PubMed
  146. Savino E, et al. 2021. Cells. 10:. PubMed
  147. Liu X, et al. 2021. Cell Prolif. 54:e13124. PubMed
  148. Doron-Mandel E, et al. 2021. EMBO J. 40:e107158. PubMed
  149. Lennox AL, et al. 2020. Neuron. 404:106. PubMed
  150. Pecori F, et al. 2021. Cell Reports. 36(2):109361. PubMed
  151. Aarts CEM, et al. 2021. Stem Cell Research. 54:102444. PubMed
  152. Zhang K, et al. 2021. Neuron. 109(12):1949-1962.e6. PubMed
  153. Aprigliano R, et al. 2021. Cell Reports Medicine. 2(4):100240. PubMed
  154. Pantier R, et al. 2021. Molecular Cell. 81(4):845-858.e8. PubMed
  155. Parlanti P, et al. 2020. Exp Eye Res. 194:107998. PubMed
  156. Toma JS, et al. 2020. Eneuro. 7:00. PubMed
  157. Solis-Castro OO, et al. 2020. Stem Cells Transl Med. 1.390277778. PubMed
  158. Ucuncu E, et al. 2020. Nat Commun. 4.685416667. PubMed
  159. LI Y, et al. 2017. Proc Natl Acad Sci U S A. 114(2):E209-E218. PubMed
  160. Jiang G, et al. 2016. Stem Cells Trans Med. 5(12):1595-1606. PubMed
  161. Martin C, et al. 2016. Genes Dev. 30: 2158 - 2172. PubMed
  162. Kida H, et al. 2016. Cereb Cortex. 10.1093/cercor/bhw134. PubMed
  163. Janssens S, et al. 2018. mSystems. 3. PubMed
  164. Thomas RA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  165. Tripathy R, et al. 2018. Neuron. 100:1354. PubMed
  166. Lenz KM, et al. 2018. J Neurosci. 38:8044. PubMed
  167. Nam H et al. 2019. Elife. 8 pii: e46683. PubMed
  168. Boucherie C, et al. 2018. Mol Psychiatry. 23:723. PubMed
  169. Leibinger M et al. 2019. Commun Biol. 0.304166667 . PubMed
  170. Mura M et al. 2019. Stem Cell Res. 1727:37:00 . PubMed
  171. Hansen M et al. 2017. Stem cell research. 25:34-37 . PubMed
  172. Yang SC, et al. 2019. FASEB J. 33:10577. PubMed
  173. Qiang L, et al. 2019. Hum Mol Genet. 28:1136. PubMed
  174. Iwasa N, et al. 2021. Front Cell Neurosci. 15:605030. PubMed
  175. Boshans LL, et al. 2021. Sci Rep. 11:3552. PubMed
  176. Weiss FD, et al. 2021. Nat Commun. 12:2919. PubMed
  177. Mallach A, et al. 2021. Cells. 10:. PubMed
  178. Hernandez-Clavijo A, et al. 2022. Cell Physiol Biochem. 56:254. PubMed
  179. Wang W, et al. 2021. EMBO J. 40:e106771. PubMed
  180. Lin YC, et al. 2021. Nat Neurosci. 24:1077. PubMed
  181. Lim JY, et al. 2021. Stem Cell Res Ther. 12:402. PubMed
  182. Mifsud KR, et al. 2021. Nat Commun. 12:4737. PubMed
  183. Li Y, et al. 2022. Front Neurosci. 16:945277. PubMed
  184. Kim K, et al. 2015. PLoS One. 10: 0142693. PubMed
  185. Mazzulli J, et al. 2016. Proc Natl Acad Sci U S A. 113: 1931 - 1936. PubMed
  186. Soares V, et al. 2016. Neuro Oncology. 10.1093/neuonc/now099. PubMed
  187. Mikami Y, et al. 2016. EBioMedicine. 11: 253-261. PubMed
  188. Pal-Ghosh S, et al. 2020. Invest Ophthalmol Vis Sci. 61:01:00. PubMed
  189. Janz A, et al. 2021. Stem Cell Research. 53:102256. PubMed
  190. Catanese A, et al. 2019. Autophagy. 15:1719. PubMed
  191. Pettingill P, et al. 2019. Brain. 142:3852. PubMed
  192. Wang SE, et al. 2019. Exp Neurobiol. 28:537. PubMed
  193. Song Z, et al. 2019. Front Cell Dev Biol. 0.352083333. PubMed
  194. Wang L et al. 2016. The Journal of comparative neurology. 524(11):2322-34 . PubMed
  195. Hansen M et al. 2017. Stem cell research. 25:42-45 . PubMed
  196. Herdy J et al. 2019. Elife. 8 pii: e41356. PubMed
  197. Vicario N et al. 2019. Molecular neurobiology. 56(11):7338-7354 . PubMed
  198. Child KM et al. 2018. The Journal of Neuroscience. 38(31):6806-6824 . PubMed
  199. Fujitani M, et al. 2017. Mol Psychiatry. 22:364. PubMed
  200. Hockman D, et al. 2018. Dev Biol. 444:s308. PubMed
  201. Barbiero I, et al. 2017. Hum Mol Genet. 26:3520. PubMed
  202. Coleman JH, et al. 2019. J Neurosci. 39:814. PubMed
  203. Luo C et al. 2019. eLife. 8 pii: e40197. PubMed
  204. Liu L et al. 2017. Cell metabolism. 26(5):719-737 . PubMed
  205. Knudsen JG et al. 2018. Cell metabolism. 29(2):430-442 . PubMed
  206. Millan‐Zambrano G et al. 2018. Molecular cell. 72(4):625-635 . PubMed
  207. Sevilla A et al. 2018. Stem cell research. 29:99-102 . PubMed
  208. Muthusamy N, et al. 2018. Sci Rep. 8:1766. PubMed
  209. Iyer AA, et al. 2022. Elife. 11:. PubMed
  210. Cheng Y, et al. 2022. Nat Commun. 13:4418. PubMed
  211. Ramirez S, et al. 2021. Cells. 10:. PubMed
  212. Wareham LK, et al. 2021. iScience. 24:103141. PubMed
  213. Abe K, et al. 2021. Biophys J. 120:3566. PubMed
  214. Mura M, et al. 2019. Stem Cell Research. 42:101658. PubMed
  215. Alkobtawi M, et al. 2021. Cell Reports. 35(12):109289. PubMed
  216. Li W, et al. 2021. Stem Cell Research. 53:102259. PubMed
  217. Haas M, et al. 2016. Cell Rep. 15:2251-2265. PubMed
  218. Itoh Y, et al. 2016. Proc Natl Acad Sci U S A. 113: 2955 - 2964. PubMed
  219. Nagao M, et al. 2016. Nat Commun. 7:11102. PubMed
  220. Taverna E, et al. 2016. Sci Rep. 6:21206. PubMed
  221. Ulbrich L, et al. 2016. Biochem J. 473: 423 - 434. PubMed
  222. Barry D, et al. 2012. J Neurosci. 32:6209-6219. PubMed
  223. Kuwahara H, et al. 2018. Sci Rep. 8:4377. PubMed
  224. Anne Jacob et al. 2018. Journal of neurochemistry. 146(3):251-268 . PubMed
  225. Lehrman EK et al. 2018. Neuron. 100(1):120-134 . PubMed
  226. Valdez C, et al. 2017. Hum Mol Genet. 26:4861. PubMed
  227. Moakley D, et al. 2019. Sci Rep. 9:10835. PubMed
  228. Malkemper EP, et al. 2018. Biol Open. 7:bio034462. PubMed
  229. Stratton JA et al. 2018. Cell reports. 24(10):2561-2572 . PubMed
  230. Neurohr GE, et al. 2019. Cell. 176:1083. PubMed
  231. Hermanto Y et al. 2019. Journal of neuroscience research. 97(7):828-845 . PubMed
  232. An D, et al. 2019. Elife. 8:e44423. PubMed
  233. Voronova A et al. 2017. Neuron. 94(3):500-516 . PubMed
  234. Hilla AM et al. 2017. The Journal of Neuroscience. 37(25):6113-6124 . PubMed
  235. Bustos F, et al. 2018. Cell Rep. 2.06875. PubMed
  236. Mayanagi T, et al. 2020. Front Cell Neurosci. 0.933333333. PubMed
  237. Arsić A, et al. 2020. Sci Rep. 10:6441. PubMed
  238. Edwards G, et al. 2020. Cell Death Dis. 11:254. PubMed
  239. Nishimura K, et al. 2017. PLoS One. 12:e0170568. PubMed
  240. Roselló-Busquets C, et al. 2020. Front Mol Neurosci. 13:56. PubMed
  241. Wang X, et al. 2019. Front Neurosci. 1.324305556. PubMed
  242. Guerriero I, et al. 2021. PLoS One. 16:e0253828. PubMed
  243. Diao X, et al. 2021. Cells. 10:. PubMed
  244. Lamotte JD, et al. 2021. Front Pharmacol. 11:617867. PubMed
  245. Paik S, et al. 2021. Biomedicines. 9:. PubMed
  246. Nehme R, et al. 2022. Nat Commun. 13:3690. PubMed
  247. Xia L, et al. 2022. Front Pharmacol. 13:881195. PubMed
  248. Zhang L, et al. 2022. Front Aging Neurosci. 14:926485. PubMed
  249. Lu P, et al. 2022. Invest Ophthalmol Vis Sci. 63:18. PubMed
  250. Heuermann ML, et al. 2022. Front Cell Neurosci. 16:841864. PubMed
  251. McSweeney D, et al. 2022. iScience. 25:105187. PubMed
  252. Caiazzo M, et al. 2016. Nat Mater. 0.1038/nmat4536. PubMed
  253. Fan C, et al. 2016. Sci Rep. 6:19579. PubMed
  254. Vanderperre B, et al. 2016. PLoS Genet. 12: 1006056. PubMed
  255. Wang T, et al. 2016. Nat Commun. 7: 12976. PubMed
  256. Pei S, et al. 2016. Sci Rep. 6:33822. PubMed
  257. M Rodriguez, S Noctor, E Muñoz 2016. PLoS One. 11:e0167063. PubMed
  258. Ahn LY, et al. 2021. J Neurosci Res. 99:110. PubMed
  259. Black JB, et al. 2020. Cell Rep. 33:108460. PubMed
  260. Birkhoff JC, et al. 2020. Hum Mol Genet. 29:2535. PubMed
  261. Pereiro X, et al. 2020. Cells. 9:00. PubMed
  262. Berenguer-Escuder C, et al. 2020. Human Molecular Genetics. 29(8):1353-1364. PubMed
  263. Tapias A, et al. 2021. eLife. 10:00. PubMed
  264. Dong L, et al. 2021. Stem Cell Research. 53:102260. PubMed
  265. Zhang T, et al. 2021. STAR Protocols. 2(1):100346. PubMed
  266. Arribas-Carreira L, et al. 2019. Stem Cell Research. 39:101503. PubMed
  267. Schoger E, et al. 2021. Stem Cell Research. 56:102518. PubMed
  268. Klima S, et al. 2020. ALTEX. . PubMed
  269. Banal C, et al. 2020. Stem Cell Research. 72.78888889. PubMed
  270. Zhao J, et al. 2020. Aging (Albany NY). 12:5590. PubMed
  271. Themeli M, et al. 2020. Stem Cell Reports. 14:300. PubMed
  272. Ding D, et al. 2020. J Otol. 15:36. PubMed
  273. Ilouz R et al. 2017. eLife. 6 pii: e17681. PubMed
  274. Kwart D et al. 2019. Neuron. 104(2):256-270 . PubMed
  275. Di Bella DJ, et al. 2019. Cell Rep. 28:2264. PubMed
  276. Velychko S et al. 2019. Cell reports. 27(1):30-39 . PubMed
  277. Kim J, et al. 2018. Development. 145. PubMed
  278. Yang T et al. 2018. Cell reports. 24(10):2694-2708 . PubMed
  279. Cheng LS, et al. 2017. Pediatr Res. 81:838. PubMed
  280. Augé E, et al. 2018. Sci Rep. 8:13525. PubMed
  281. Shin BC et al. 2018. The Journal of Neuroscience. 38(44):9579-9599 . PubMed
  282. Cárdenas A et al. 2018. Cell. 174(3):590-606 . PubMed
  283. Goffena J, et al. 2018. Nat Commun. 9:889. PubMed
  284. Ogawa Y, et al. 2017. PLoS One. 12(6):e0178978. PubMed
  285. Ha GH, et al. 2022. Aging (Albany NY). 14:. PubMed
  286. Meyer Zu Reckendorf S, et al. 2022. J Neurosci. 42:2474. PubMed
  287. van Niekerk EA, et al. 2022. Cell Rep Methods. 2:100255. PubMed
  288. Nouri P, et al. 2022. Cells. 11:. PubMed
  289. Amo-Aparicio J, et al. 2021. Theranostics. 11:9805. PubMed
  290. Fagerlund I, et al. 2021. Cells. 11:. PubMed
  291. Petrovic A, et al. 2022. Int J Mol Sci. 23:. PubMed
  292. Colombo S, et al. 2022. Development. 149:. PubMed
  293. Sidoli M, et al. 2021. J Neurosci. 41:4536. PubMed
  294. Simone R, et al. 2021. Nature. 594:117. PubMed
  295. Li A, et al. 2021. STAR Protoc. 2:100580. PubMed
  296. Osuka S, et al. 2021. J Clin Invest. 131: . PubMed
  297. Lasman L, et al. 2020. Genes Dev. 34:1373. PubMed
  298. Wong HS, et al. 2021. Cell. . PubMed
  299. Kim JW, et al. 2020. Cell Stem Cell. 27(4):633-645.e7. PubMed
  300. Evsen L, et al. 2020. Development. 147:00:00. PubMed
  301. Huang YA, et al. 2020. J Cell Sci. 133:00:00. PubMed
  302. Levin G, et al. 2020. Front Bioeng Biotechnol. 0.663888889. PubMed
  303. Seo HH, et al. 2020. Emerg Microbes Infect. 1.724305556. PubMed
  304. Laura Kerosuo, Marianne E. Bronner 2016. Cell Rep. 17:2648-2659. PubMed
  305. George L, et al. 2016. Dev Biol. 413:70-85. PubMed
  306. Ferletta M, et al. 2011. Int J Cancer. 129:45-60. PubMed
  307. Chau KF, et al. 2018. Elife. 19:E663. PubMed
  308. Sun S et al. 2018. Cell. 174(5):1247-1263 . PubMed
  309. Yi‐Lan Weng et al. 2018. Neuron. 97(2):313-325 . PubMed
  310. Bachmann SO, et al. 2019. Transl Psychiatry. 9:29. PubMed
  311. Sabo JK, et al. 2017. Ann Neurol. 81:560. PubMed
  312. Gao L, et al. 2019. Front Cell Neurosci. 13:316. PubMed
  313. Shao Q et al. 2019. PLoS One. 14(6):e0218811 . PubMed
  314. Mohlin S, et al. 2019. EMBO Mol Med. 11:e10058. PubMed
  315. Ibañez Rodriguez MP et al. 2018. The Journal of comparative neurology. 526(15):2462-2481 . PubMed
  316. Duan RS, et al. 2018. Cell Death Differ. 25:1598. PubMed
  317. Pollen AA, et al. 2019. Cell. 176:743. PubMed
  318. Corman A, et al. 2019. Cell Chem Biol. 26:235. PubMed
  319. Molotkov A et al. 2017. Developmental cell. 41(5):511-526 . PubMed
  320. Yang C, et al. 2020. Neuron. 105:276. PubMed
  321. Marchetta P, et al. 2020. Front Aging Neurosci. 12:83. PubMed
  322. Zheng Z, et al. 2021. Cell Biol Toxicol. Online ahead of prin. PubMed
  323. Lim SH, et al. 2020. J Cell Sci. . PubMed
  324. Salti A, et al. 2021. Cells. 10:. PubMed
  325. Araki R, et al. 2021. Heliyon. 7:e08071. PubMed
  326. Ye E, et al. 2022. Int J Oncol. 60:. PubMed
  327. Taïb S, et al. 2022. Elife. 11:. PubMed
  328. Bérenger-Currias NM, et al. 2022. J Tissue Eng. 13:20417314221103042. PubMed
  329. Wirt S, et al. 2010. J Cell Biol. 191:809-825. PubMed
  330. Wang Q, et al. 2016. Sci Rep. 6:19003. PubMed
  331. Petracca Y, et al. 2016. Development. 143: 880 - 891. PubMed
  332. Lalli M, et al. 2016. Hum Mol Genet. 25: 1294-1306. PubMed
  333. Thakurela S, et al. 2016. Sci Rep. 6: 25828. PubMed
  334. Bedogni F, et al. 2016. Cereb Cortex. 26: 2517 - 2529. PubMed
  335. Landegger L, et al. 2017. Nat Biotechnol. 35:280-284. PubMed
  336. Pournasr B, et al. 2020. Stem Cell Res. 48:101953. PubMed
  337. Trapecar M, et al. 2021. Sci Adv. 7:00. PubMed
  338. Smith KE, et al. 2020. Journal of Neuroscience Research. 99(2):679-698. PubMed
  339. Isaja L, et al. 2021. Stem Cell Research. 53:102325. PubMed
  340. Elsayed AK, et al. 2021. Stem Cell Research. 56:102500. PubMed
  341. Bargagna-Mohan P, et al. 2020. J Neurosci Res. . PubMed
  342. Lee N, et al. 2021. Biochem Biophys Rep. 100973:26. PubMed
  343. Khong ZJ, et al. 2020. Cell Death Dis. 11:182. PubMed
  344. Pinheiro H, et al. 2018. Front Pharmacol. 0.527083333. PubMed
  345. Ichihara–Tanaka K, et al. 2017. J Histochem Cytochem. 65:513. PubMed
  346. Harrington AJ et al. 2016. eLife. 5 pii: e20059. PubMed
  347. Michael Lerche et al. 2017. Structure (London, England : 1993). 25(8):1175-1186 . PubMed
  348. Larhammar M et al. 2017. eLife. 6 pii: e20725. PubMed
  349. Lavado A et al. 2018. Dev Cell. 47(5):576-591 . PubMed
  350. Freeman S et al. 2019. EMBO Rep. 20(9):e47097 . PubMed
  351. Kaur T, et al. 2019. Front Neurosci. 13:620. PubMed
  352. Nash B et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed
  353. Sarkar C, et al. 2019. Autophagy. N/A. PubMed
  354. Tramarin M, et al. 2018. Hum Mol Genet. 27:2052. PubMed
  355. Xue J, et al. 2017. ACS Appl Mater Interfaces. 9:12299. PubMed
  356. Toda T, et al. 2017. Cell Stem Cell. 21:618. PubMed
  357. Amaral JD, et al. 2019. Front Chem. 7:15. PubMed
  358. Wang XW, et al. 2018. Cell Rep. 24:2540. PubMed
  359. Tavano S et al. 2018. Neuron. 97(6):1299-1314 . PubMed
  360. Luisier R, et al. 2018. Nat Commun. 8:6458. PubMed
  361. Fujiwara N, et al. 2022. Pediatr Surg Int. 39:18. PubMed
  362. Zhu Z, et al. 2022. Aging Cell. 21:e13587. PubMed
  363. Schaeffer J, et al. 2022. Front Cell Dev Biol. 10:917589. PubMed
  364. Li J, et al. 2021. Neural Plast. 2021:4894881. PubMed
  365. Wilmerding A, et al. 2021. Int J Mol Sci. 22:. PubMed
  366. Hu D, et al. 2021. Nat Commun. 12:5305. PubMed
  367. Russo-Savage L, et al. 2020. Neurobiol Aging. 95:69. PubMed
  368. Urciuolo A, et al. 2020. Nat Biomed Eng. 4:901. PubMed
  369. Sadick JS, et al. 2020. Ann Biomed Eng. 48:2218. PubMed
  370. Lecomte A, et al. 2020. Adv Biosyst. e2000114:4. PubMed
  371. Wang L, et al. 2020. Nat Commun. 3.2625. PubMed
  372. Sheehan CJ, et al. 2020. Development. 147:00:00. PubMed
  373. Zabolocki M, et al. 2020. Nat Commun. 4.3125. PubMed
  374. Liu R, et al. 2021. Oncol Lett. 21:06. PubMed
  375. Zhang X, et al. 2020. Sci Adv. 6:00. PubMed
  376. Sadick J, et al. 2016. Sci Rep. 6: 33999. PubMed
  377. Guo S, Du Y, Liu X 2016. Nat Commun. 7:12230. PubMed
  378. Kushwaha R, et al. 2016. Stem Cell Reports. 6:772-783. PubMed
  379. Paquet D, et al. 2016. Nature. 533: 125-129. PubMed
  380. Binder Z, et al. 2016. PLoS One. 11: 0150271. PubMed
  381. He H, et al. 2016. J Neurosci. 36: 3079 - 3091. PubMed
  382. Lehtonen Ŝ et al. 2018. Stem cell research. 30:96-99 . PubMed
  383. Qiang L et al. 2018. Current biology : CB. 28(13):2181-2189 . PubMed
  384. Hor JH, et al. 2018. Cell Death Dis. 9:1100. PubMed
  385. Gupta S et al. 2017. Journal of neurochemistry. 145(3):188-203 . PubMed
  386. Howlett EH, et al. 2017. Hum Mol Genet. 26:4340. PubMed
  387. Zunke F et al. 2017. Neuron. 97(1):92-107 . PubMed
  388. Fernandes KA, et al. 2018. Exp Eye Res. 171:54. PubMed
  389. Linkous A et al. 2019. Cell reports. 26(12):3203-3211 . PubMed
  390. Pronin A, et al. 2019. Front Mol Neurosci. 12:36. PubMed
  391. Meijer M et al. 2019. Cell Rep. 27(7):2199-2211 . PubMed
  392. Lin CI et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed
  393. Auboyer L et al. 2019. Stem Cell Res. 1723:41:00 . PubMed
  394. Kurtenbach S et al. 2017. PloS one. 12(11):e0187576 . PubMed
  395. Yu M et al. 2017. Cell research. 27(12):1441-1465 . PubMed
  396. Huh CJ et al. 2016. eLife. 5 pii: e18648. PubMed
  397. Li J, et al. 2018. Neural Plast. 2018:6890613. PubMed
  398. Chen YT, et al. 2019. Stem Cell Res Ther. 0.6875. PubMed
  399. Syal C, et al. 2020. Theranostics. 10:6337. PubMed
  400. de Matos AM, et al. 2020. J Med Chem. 63:11663. PubMed
  401. Calamini B, et al. 2021. Dis Model Mech. 14:. PubMed
  402. Gandhi S, et al. 2021. Development. 148:. PubMed
  403. Stern S, et al. 2021. Neuron. 109:3436. PubMed
  404. Nath M, et al. 2022. Eneuro. 9:. PubMed
  405. Pinto M, et al. 2016. J Cell Biol. 212: 789 - 801. PubMed
  406. Okamoto M, et al. 2016. Nat Commun. 7: 11349. PubMed
  407. Liu X, et al. 2016. Nat Commun. 7:11508. PubMed
  408. Grandi FC, et al. 2020. Front Mol Neurosci. 0.599305556. PubMed
  409. Ewan EE, et al. 2021. Sci Rep. 0.718055556. PubMed
  410. Brievac D, et al. 2020. Journal of Neurochemistry. 157(3):666-683. PubMed
  411. Hu Z, et al. 2020. Cell Rep. 107657:31. PubMed
  412. Gilliam EA, et al. 2020. American Journal of Physiology-Gastrointestinal and Liver Physiology. 319(2):G261-G279.. PubMed
  413. Dionisi C, et al. 2020. Sci Rep. 10:7752. PubMed
  414. Lindsay CD, et al. 2019. Acta Biomater. 95:225. PubMed
  415. Makdissy N, et al. 2018. Stem Cell Res Ther. 0.466666667. PubMed
  416. Mettang M, et al. 2018. FASEB J. 32:1916. PubMed
  417. Chen X et al. 2017. Developmental cell. 43(5):563-576 . PubMed
  418. Hegarty DM, et al. 2017. J Comp Neurol. 525:2019. PubMed
  419. Tsuboi M, et al. 2018. Dev Cell. 47:758. PubMed
  420. Sharma N et al. 2019. Neuron. 102(2):390-406 . PubMed
  421. Mo J, et al. 2017. Invest Ophthalmol Vis Sci. 58:137. PubMed
  422. Rhee HJ et al. 2019. Cell Rep. 27(7):2212-2228 . PubMed
  423. Makar T, et al. 2018. Stem Cell Res Ther. 9:127. PubMed
  424. Debadrita Bhattacharya et al. 2018. eLife. 7 pii: e40556. PubMed
  425. Zahr SK et al. 2018. Neuron. 97(3):520-537 . PubMed
  426. Kim YJ, et al. 2018. Neuron. 100:1180. PubMed
  427. Contreras E, et al. 2022. Cell Tissue Res. :. PubMed
  428. Sluysmans S, et al. 2021. Mol Biol Cell. 32:ar34. PubMed
  429. Ma C, et al. 2022. Int J Mol Med. 50:. PubMed
  430. Khan M, et al. 2021. Cell. 184:5932. PubMed
  431. Xu PF, et al. 2021. Nature Communications. 12(1):3277. PubMed
  432. Anderson EM, et al. 2021. Addiction Biology. :e13060. PubMed
  433. Lin NH, et al. 2021. The FASEB Journal. 35(5):e21614. PubMed
  434. Leibinger M, et al. 2021. Nature Communications. 12(1):391. PubMed
  435. Huang S, et al. 2020. Cell Rep. 33:108394. PubMed
  436. Rubio A, et al. 2016. Sci Rep. 6:37540. PubMed
  437. Intoh A, et al. 2016. Hum Mol Genet. 10.1093/hmg/ddw053. PubMed
  438. Sancho-Martinez I, et al. 2016. Nat Commun. 7:10743. PubMed
  439. Jouhilahti E, et al. 2008. J Histochem Cytochem. 56:1113-1119. PubMed
  440. Flaherty E,et al. 2017. NPJ Schizophr.. 10.1038/s41537-017-0033-5. PubMed
  441. Ryan T, et al. 2018. Nat Commun. 9:817. PubMed
  442. Moon KH et al. 2018. Developmental cell. 44(1):13-28 . PubMed
  443. Xu Z, et al. 2019. Front Neurosci. 12:970. PubMed
  444. Joanna Ruth Appel et al. 2018. The Journal of Neuroscience. 38(26):5949-5968 . PubMed
  445. Vyas P, et al. 2019. Sci Rep. 9:5549. PubMed
  446. Zhang N, et al. 2019. Adv Sci (Weinh). 6:1800808. PubMed
  447. Singh K, et al. 2018. Front Mol Neurosci. 11:30. PubMed
  448. Friocourt F et al. 2019. The Journal of comparative neurology. 527(12):2009-2029 . PubMed
  449. Weng YL, et al. 2017. Neuron. 94:337. PubMed
  450. Espuny‐Camacho I et al. 2017. Neuron. 93(5):1066-1081 . PubMed
  451. Park JH, et al. 2018. Mol Cell Biol. 38:e00217. PubMed
  452. Ozaki K, et al. 2019. Invest Ophthalmol Vis Sci. 60:4151. PubMed
  453. Llères D, et al. 2019. Genome Biol. 1.022222222. PubMed
  454. Dourado NS, et al. 2020. Front Aging Neurosci. 12:119. PubMed
  455. Götzl JK, et al. 2018. Mol Neurodegener. 13:48. PubMed
  456. Borys BS, et al. 2021. Stem Cell Res Ther. 12:55. PubMed
  457. Little JN, et al. 2021. J Neurosci. 41:3344. PubMed
  458. Sanchez CG, et al. 2021. Commun Biol. 4:736. PubMed
  459. Wang L, et al. 2021. Nat Med. 27:1600. PubMed
  460. Sepehrimanesh M, et al. 2021. STAR Protoc. 2:100917. PubMed
  461. Barbuti PA, et al. 2021. Sci Rep. 11:21946. PubMed
  462. Meng X, et al. 2022. Proc Natl Acad Sci U S A. 119:. PubMed
  463. Argolo DS, et al. 2022. Int J Tryptophan Res. 15:11786469211069946. PubMed
  464. Li Y, et al. 2022. J Cell Biol. 221:. PubMed
  465. Yamamoto Y, et al. 2022. Life Sci Alliance. 5:. PubMed
  466. Chen J, et al. 2021. Int J Mol Sci. 23:. PubMed
  467. Zhang H, et al. 2022. Elife. 11:. PubMed
  468. Tang J, et al. 2022. Antioxidants (Basel). 11:. PubMed
  469. Xue Y, et al. 2016. Nat Neurosci. 19: 807-15. PubMed
  470. Muscat A, et al. 2016. Clin Cancer Res. 22: 3560 - 3570. PubMed
  471. Sandor C, et al. 2017. Hum Mol Genet. 10.1093/hmg/ddw412. PubMed
  472. Ingersoll MA, et al. 2020. Sci Adv. 6:00. PubMed
  473. Jiang B, et al. 2020. Sci Adv. 6:00. PubMed
  474. Barbuti PA, et al. 2020. Cells. 9:00. PubMed
  475. Vila-Cejudo M, et al. 2018. Journal of Assisted Reproduction and Genetics. 36(1):99-111. PubMed
  476. Koinuma S, et al. 2020. Journal of Neurochemistry. 157(4):1196-1206. PubMed
  477. Dementyeva EV, et al. 2021. Stem Cell Research. 53:102344. PubMed
  478. Han JS, et al. 2020. Proc Natl Acad Sci U S A. 23073:117. PubMed
  479. Gupta S, et al. 2021. STAR Protoc. 100319:2. PubMed
  480. Hertzano R, et al. 2020. Laryngoscope. . PubMed
  481. Stathakos P, et al. 2020. Autophagy. :1. PubMed
  482. Huang YA, et al. 2019. J Neurosci. 39:7408. PubMed
  483. Dang LT, et al. 2020. Front Cell Neurosci. 14:122. PubMed
  484. Sloan SA et al. 2017. Neuron. 95(4):779-790 . PubMed
  485. Shao Q et al. 2017. The Journal of Neuroscience. 37(23):5620-5633 . PubMed
  486. Wu JS et al. 2017. The Journal of comparative neurology. 526(3):425-438 . PubMed
  487. Wu C, et al. 2019. Cell Rep. 26:1143. PubMed
  488. Vassilev V, et al. 2017. Dev Cell. 43:463. PubMed
  489. Kim J, et al. 2017. Histochem Cell Biol. 148:489. PubMed
  490. Thayer JA, et al. 2019. Autophagy. 7:1-14. PubMed
  491. Liu WA, et al. 2018. Genes Dev. 32:763. PubMed
  492. Trajkovic K, et al. 2019. PLoS One. 14:e0211727. PubMed
  493. Oksanen M et al. 2018. Stem cell research. 31:181-185 . PubMed
  494. Johansson E, et al. 2017. Cell Rep. 10.1016/j.celrep.2017.07.049. PubMed
  495. Reyes RV, et al. 2022. Front Neurosci. 16:908719. PubMed
  496. He B, et al. 2021. J Anat. 239:913. PubMed
  497. Arsic A, et al. 2022. Nat Commun. 13:314. PubMed
  498. Calamini B, et al. 2021. Dis Model Mech. . PubMed
  499. Brown D, et al. 2021. Neurotherapeutics. 18:387. PubMed
  500. Wang M, et al. 2021. Neuron. 109:257. PubMed
  501. Ren J, et al. 2021. Cells. 10:. PubMed
  502. Cui K, et al. 2020. Microsyst Nanoeng. 6:49. PubMed
  503. Cuddy LK, et al. 2021. STAR Protoc. 100340:2. PubMed
  504. Matern MS, et al. 2020. Development. :147. PubMed
  505. Nikulina E, et al. 2020. FEBS Lett. 1389:594. PubMed
  506. Ghita L, et al. 2021. Journal of Neuroscience Research. :. PubMed
  507. Simon DJ, et al. 2021. Developmental Cell. 56(7):976-984.e3. PubMed
  508. Maor-Nof M, et al. 2021. Cell. 184(3):689-708.e20. PubMed
  509. Kraemer BR, et al. 2020. Neuroscience. 453:222-236. PubMed
  510. Schörnig M, et al. 2021. Elife. 10:00. PubMed
  511. Camilieri-Asch V, et al. 2020. Front Neuroanat. 14:560534. PubMed
  512. Durak O, et al. 2016. Nat Neurosci. 19:1477-1488. PubMed
  513. Drobish J, et al. 2016. Toxicol Sci. 154(2):309-319. PubMed
  514. Marchetto M, et al. 2016. Mol Psychiatry. 10.1038/mp.2016.95. PubMed
  515. Wang W, et al. 2016. Nat Commun. 7:10936. PubMed
  516. Tanimoto R, et al. 2016. Sci Rep. 6:22071. PubMed
  517. Wu X, et al. 2018. Cell. 172:423. PubMed
  518. Buijsen RAM et al. 2018. Stem cell research. 29:125-128 . PubMed
  519. Miquel‐Serra L et al. 2018. Stem cell research. 24:155-159 . PubMed
  520. Senft AD, et al. 2018. Cell Rep. 24:1977. PubMed
  521. Gao L, et al. 2019. Sci Rep. 9:3462. PubMed
  522. Xu Z, et al. 2018. Development. 145:. PubMed
  523. Christiansen EM, et al. 2018. Cell. 173:792. PubMed
  524. Rich CA, et al. 2018. Glia. 66:2617. PubMed
  525. Heil C, et al. 2019. Open Biol. 9:180145. PubMed
  526. Wanner R, et al. 2019. Front Neurol. 10:310. PubMed
  527. Hickey SL et al. 2019. Cell reports. 27(6):1699-1711 . PubMed
  528. Suarato G, et al. 2017. Biomaterials. 112:176. PubMed
  529. Watanabe Y, et al. 2018. Development. 145. PubMed
  530. Chanda S et al. 2019. Cell Stem Cell. 25(1):103-119 . PubMed
  531. Wu Z, et al. 2019. Neuron. 101:635. PubMed
  532. Bachmann SB, et al. 2019. Cell Rep. 27:3305. PubMed
  533. Kaplan A, et al. 2017. Neuron. 93:1082. PubMed
  534. Tozer S, et al. 2017. Neuron. 93:542. PubMed
  535. Leibinger M et al. 2017. Proceedings of the National Academy of Sciences of the United States of America. 114(27):E5454-E5463 . PubMed
  536. Syc–Mazurek SB, et al. 2018. Cell Death Dis. 1.135416667. PubMed
  537. Kang PH, et al. 2020. Mol Biol Cell. 31:386. PubMed
  538. Tehrani S, et al. 2018. Sci Rep. 8:4453. PubMed
  539. Russo R, et al. 2018. Cell Death Dis. 1.05625. PubMed
  540. Suenkel C, et al. 2020. Cell Reports. 30(7):2170-2179. PubMed
  541. Peitz M, et al. 2020. STAR Protoc. 1:100038. PubMed
  542. Petrovic A, et al. 2021. Front Cell Neurosci. 15:661492. PubMed
  543. Liang D, et al. 2021. Nat Neurosci. 24:941. PubMed
  544. Lautz JD, et al. 2021. Cell Rep. 37:110076. PubMed
  545. De La Rossa A, et al. 2022. Elife. 11:. PubMed
  546. Rabadán MA, et al. 2022. Nat Commun. 13:3340. PubMed
  547. Williams LA, et al. 2022. Mol Ther Nucleic Acids. 29:189. PubMed
  548. Vahsen BF, et al. 2022. Sci Rep. 12:12606. PubMed
  549. Sefiani A, et al. 2022. Sci Rep. 12:13125. PubMed
  550. Tay SH, et al. 2021. Methods Mol Biol. 2549:359. PubMed
  551. Fisher ES, et al. 2022. J Neuroinflammation. 19:266. PubMed
  552. Quintes S, et al. 2016. Nat Neurosci. 10.1038/nn.4321. PubMed
  553. Demais V, et al. 2016. J Neurosci. 36: 8012 - 8025. PubMed
  554. Borromeo M, et al. 2016. Cell Rep. 16:1259-1272. PubMed
  555. Borgs L, et al. 2016. Sci Rep. 6: 33377. PubMed
  556. Enriquez‐Rios V et al. 2017. The Journal of Neuroscience. 37(4):893-905 . PubMed
  557. Shi W, et al. 2017. Nat Neurosci. 10.1038/nn.4519. PubMed
  558. Brann DH, et al. 2020. Sci Adv. 6:00. PubMed
  559. McNeely KC, et al. 2020. Proc Natl Acad Sci U S A. 117:9584. PubMed
  560. Li Y, et al. 2021. Stem Cell Research. 55:102460. PubMed
  561. Hilla AM, et al. 2018. BIO-PROTOCOL. 8(16):e2979. PubMed
  562. Kitajima R, et al. 2020. Stem Cell Res. 101749:44. PubMed
  563. Fouda AY, et al. 2020. Invest Ophthalmol Vis Sci. 51:61. PubMed
  564. Yao H, et al. 2020. Sci Rep. 10:17445. PubMed
  565. Matthies D, et al. 2020. Sci Rep. 10:11953. PubMed
  566. Hattori Y, et al. 2020. Nat Commun. 11:1631. PubMed
  567. Duncan DS, et al. 2018. Front Neurosci. 0.9875. PubMed
  568. Welsbie DS et al. 2017. Neuron. 94(6):1142-1154 . PubMed
  569. Belle M et al. 2017. Cell. 169(1):161-173 . PubMed
  570. Walker LJ et al. 2017. eLife. 6 pii: e22540. PubMed
  571. Mura M et al. 2019. Stem Cell Res. 1727:31:00 . PubMed
  572. Gao F et al. 2019. Mol Cell. 75(5):891-904 . PubMed
  573. Kurabayashi N, et al. 2018. Development. 145. PubMed
  574. Miesfeld JB et al. 2017. Gene expression patterns : GEP. 27:114-121 . PubMed
  575. Calatayud C, et al. 2019. Sci Rep. 9:6811. PubMed
  576. Pai EL et al. 2019. Cell reports. 26(5):1157-1173 . PubMed
  577. Teng X, et al. 2018. Thyroid. 28:667. PubMed
  578. Sun L, et al. 2017. Oncotarget. 8:40065. PubMed
  579. Spitalieri P, et al. 2018. Front Physiol. 9:967. PubMed
  580. Erin Frey et al. 2018. eNeuro. 5(3) pii: ENEURO. PubMed
  581. Mura M et al. 2018. Stem cell research. 29:157-161 . PubMed
  582. Rantanen LM, et al. 2022. Cells. 11:. PubMed
  583. Hamity MV, et al. 2022. Invest Ophthalmol Vis Sci. 63:38. PubMed
  584. Lam AN, et al. 2021. Data Brief. 35:106897. PubMed
  585. Cui K, et al. 2022. Cell Regen. 11:7. PubMed
  586. Zhao D, et al. 2021. Cell Death Differ. 28:337. PubMed
  587. Schenk MS, et al. 2021. Transl Vis Sci Technol. 10:22. PubMed
  588. Dong Y, et al. 2021. STAR Protoc. 2:100853. PubMed
  589. Calado SM, et al. 2021. Stem Cell Research. 55:102462. PubMed
  590. Bieler M, et al. 2021. Journal of Comparative Neurology. 529(12):3194-3205. PubMed
  591. Kondo N, et al. 2020. Cancers (Basel). 12:00. PubMed
  592. Friocourt F, et al. 2017. Sci Rep. 7:37569. PubMed
  593. Fimiani C, et al. 2016. Sci Rep. 6:39311. PubMed
  594. Damiani D, et al. 2016. Nat Commun. 7:13509. PubMed
  595. Hegazy A, et al. 2016. J Biol Chem. 291: 21496 - 21509. PubMed
  596. Maison S, Liberman L, Liverman M 2016. eNeuro. 3: ENEURO.0207-16.2016. PubMed
  597. Edmondson R, Adock A, Yang L 2016. PLoS One. 11: 0158116. PubMed
  598. Jablonski K, et al. 2016. Stem Cell Reports. 8: 1119-1127. PubMed
  599. Rraklli V, et al. 2016. Stem Cell Res. 16:1-9. PubMed
  600. Kizuka Y, et al. 2016. Biochem J. 473: 21 - 30. PubMed
  601. Kim K, et al. 2013. J Cell Biol. 200:443-458. PubMed
  602. Cesca F, et al. 2012. Cell Death Differ. 19:194-208. PubMed
  603. Liu P, et al. 2017. Stem Cell Rep. 10.1016/j.stemcr.2017.05.007. PubMed
  604. Sommer A et al. 2018. Cell stem cell. 23(1):123-131 . PubMed
  605. Mains RE et al. 2018. Endocrinology. 159(7):2621-2639 . PubMed
  606. Kelly SM et al. 2018. Neuron. 99(2):345-361 . PubMed
  607. Han S, et al. 2018. Development. 145:. PubMed
  608. Friedl RM, et al. 2019. Dis Model Mech. 0.5. PubMed
  609. Khayati K, et al. 2017. FASEB J. 31:598. PubMed
  610. Comai G et al. 2019. Elife. 8 pii: e47460. PubMed
  611. Lee SG et al. 2018. Stem Cell Res. 31:197-200 . PubMed
  612. Zhu J et al. 2017. Cell stem cell. 20(3):374-384 . PubMed
  613. Gouti M, et al. 2017. Dev Cell. 41:243. PubMed
  614. Levin E et al. 2017. Scientific reports. 7(1):643 . PubMed
  615. Tokuyama MA, et al. 2018. Dev Biol. 433:287. PubMed
  616. Xie Y, et al. 2019. RNA Biol. 0.723611111. PubMed
  617. Yang D, et al. 2019. Elife. 8:e49249. PubMed
  618. Heinrich A, et al. 2020. Cell Rep. 31:107513. PubMed
  619. Park S, et al. 2020. PLoS Biol. 18:e3000296. PubMed
  620. Pappa S, et al. 2019. Proc Natl Acad Sci U S A. 116:19464. PubMed
  621. Marquardt LM, et al. 2020. Sci Adv. 6:eaaz1039. PubMed
  622. Doucet-O'Hare TT, et al. 2021. Sci Rep. 11:12893. PubMed
  623. Gandhi S, et al. 2021. Development. 148:dev193565. PubMed
  624. Ketschek A, et al. 2021. J Neurosci. 41:6637. PubMed
  625. Park SH, et al. 2021. Biochem Pharmacol. 188:114520. PubMed
  626. Oksdath Mansilla M, et al. 2021. BMC Biomed Eng. 3:6. PubMed
  627. Flores-Otero J, et al. 2007. J Neurosci. 27:14023-14034. PubMed
  628. Wang L, Hou S, Han Y 2016. Nat Neurosci. 19: 888-896. PubMed
  629. Roese-Koerner B, et al. 2016. Stem Cell Reports. 7:207-219. PubMed
  630. Choi R, et al. 2020. Laryngoscope Investig Otolaryngol. 0.885416667. PubMed
  631. Ng AQE, et al. 2020. Cell Reports. 30(5):1434-1446.e7. PubMed
  632. Hawkins FJ, et al. 2020. Cell Stem Cell. 28(1):79-95.e8. PubMed
  633. Arber C, et al. 2021. Cell Reports. 34(2):108615. PubMed
  634. Zhang X, et al. 2021. Cell Reports. 34(11):108830. PubMed
  635. Czeisler C, et al. 2016. Journal of Comparative Neurology. 524(17):3485-3502. PubMed
  636. Abreu CA, et al. 2021. Journal of Neurochemistry. 158(3):694-709. PubMed
  637. Jia L, et al. 2018. Mol Neurobiol. 55:9089. PubMed
  638. Sun W, et al. 2020. J Clin Invest. 130:345. PubMed
  639. Baek C, et al. 2018. PLoS Biol. 16:e2004162. PubMed
  640. Miyake S et al. 2015. Cell death & disease. 6:e1638 . PubMed
  641. Wang L et al. 2017. The Journal of comparative neurology. 525(13):2915-2928 . PubMed
  642. Stratton JA et al. 2017. eNeuro. 4(3) pii: ENEURO. PubMed
  643. Norsworthy MW et al. 2017. Neuron. 94(6):1112-1120 . PubMed
  644. Brekk OR et al. 2018. Molecular and cellular neurosciences. 95:1-12 . PubMed
  645. Mura M et al. 2019. Stem cell research. 1726:16:00 . PubMed
  646. Jung JS, et al. 2019. J Neurosci. 39:6425. PubMed
  647. Fan D et al. 2019. Elife. 8 pii: e49226. PubMed
  648. Sarah E Pease‐Raissi et al. 2017. Neuron. 96(2):373-386 . PubMed
  649. Sorrells SF, et al. 2019. Nat Commun. 10:2748. PubMed
  650. Lee J, et al. 2018. Invest Ophthalmol Vis Sci. 59:3531. PubMed
  651. Alexander JM et al. 2019. Elife. 8 pii: e41769. PubMed
  652. Hu D, et al. 2019. Acta Neuropathol. 137:939. PubMed
  653. Acosta S, et al. 2018. Genesis. 56:e23212. PubMed
  654. Stallings NR, et al. 2018. Sci Signal. 11:522. PubMed
  655. Diacou R et al. 2018. Cell reports. 25(9):2510-2523 . PubMed
  656. Liu Y et al. 2018. Cell stem cell. 23(5):758-771 . PubMed
  657. Umegaki Y et al. 2018. The Journal of Neuroscience. 38(21):4985-4995 . PubMed
  658. Urrea L, et al. 2018. Mol Neurobiol. 15:1630. PubMed
  659. Xu X, et al. 2022. Biology (Basel). 11:. PubMed
  660. Namchaiw P, et al. 2022. PLoS One. 17:e0273458. PubMed
  661. Wu C, et al. 2022. J Hum Genet. :. PubMed
  662. Wilmerding A, et al. 2022. Neoplasia. 24:120. PubMed
  663. Yang Y, et al. 2022. Nucleic Acids Res. 50:191. PubMed
  664. Hilton BJ, et al. 2021. Neuron. S0896-6273:00775-3. PubMed
  665. Bassil R, et al. 2021. Nat Commun. 12:5220. PubMed
  666. Vaes N, et al. 2021. EMBO Rep. 22:e51913. PubMed
  667. Bouma MJ, et al. 2019. Stem Cell Research. 41:101654. PubMed
  668. Rebs S, et al. 2021. Stem Cell Research. 53:102263. PubMed
  669. Gao T, et al. 2021. JCI Insight. 6(10):. PubMed
  670. Liu W, et al. 2020. J Exp Med. 217:00:00. PubMed
  671. Franco A, et al. 2020. Elife. 9:00. PubMed
  672. Chen W, et al. 2017. eNeuro. 3(6). PubMed
  673. Teresa Rivera, Candy Haggblom, Sandro Cosconati 2016. Nat Struct Mol Biol. 24:30-39. PubMed
  674. Jager P, et al. 2016. Nat Commun. 7:13579. PubMed
  675. Zeltner N, et al. 2016. Nat Med. 22:1421-1427. PubMed
  676. Gaitán-Peñas H, et al. 2016. Biophys J. 111:1429-1443. PubMed
  677. Zalfa C, et al. 2016. Cell Death Dis. 7:e2331. PubMed
  678. Li S, et al. 2016. Sci Rep. 6:29514. PubMed
  679. Mita T, et al. 2016. J Biol Chem. 291: 4955 - 4965. PubMed
  680. Hackelberg S, et al. 2017. PLoS One. 10.1371/journal.pone.0180427. PubMed
  681. Stepp MA, et al. 2018. Exp Eye Res. 10:113. PubMed
  682. Merten N et al. 2018. Cell chemical biology. 25(6):775-786 . PubMed
  683. Tandon R et al. 2018. Stem cell research. 33:120-124 . PubMed
  684. Kaur T et al. 2018. The Journal of comparative neurology. 526(5):824-835 . PubMed
  685. Lang C et al. 2019. Cell stem cell. 24(1):93-106 . PubMed
  686. Stylianou N, et al. 2019. Oncogene. 38:913. PubMed
  687. Tiihonen J, et al. 2019. Nat Commun. 10:3933. PubMed
  688. Park KK et al. 2017. The Journal of comparative neurology. 525(2):380-388 . PubMed
  689. Chang CH, et al. 2019. Dev Cell. 48:184. PubMed
  690. Hertz NT et al. 2019. Neuron. 103(3):412-422 . PubMed
  691. Angelim MKSC et al. 2018. Glia. 66(11):2470-2486 . PubMed
  692. Wu J et al. 2017. Cell. 168(3):473-486 . PubMed
  693. Ma S et al. 2017. Developmental cell. 41(4):366-381 . PubMed
  694. Sevilla A et al. 2017. Stem Cell Res. 25:217-220 . PubMed
  695. Crouch EE et al. 2015. The Journal of Neuroscience. 35(11):4528-39 . PubMed
  696. Liu Z, et al. 2017. Stem Cells Dev. 26:177. PubMed
  697. Maslon MM, et al. 2019. EMBO J. 38:e101244. PubMed
  698. Steevens AR, et al. 2019. Development. 146:dev170522. PubMed
  699. Liu W, et al. 2019. Invest Ophthalmol Vis Sci. 60:965. PubMed
  700. Lee JH, et al. 2019. Aging (Albany NY). 11:11541. PubMed
  701. Peng XQ, et al. 2020. Front Cell Neurosci. 0.674305556. PubMed
  702. Gangoso E, et al. 2021. Cell. 184:2454. PubMed
  703. Sun Z, et al. 2021. Aging (Albany NY). 13:12587. PubMed
  704. Chen Y, et al. 2021. Nat Methods. 18:528. PubMed
  705. Cast TP, et al. 2021. J Neurosci. 41:392. PubMed
  706. Satoh M, et al. 2021. Int J Mol Sci. 22:. PubMed
  707. Eriksen AZ, et al. 2022. STAR Protoc. 3:101383. PubMed
  708. Kempfle JS, et al. 2021. Front Cell Neurosci. 15:666706. PubMed
  709. Guan Y, et al. 2021. Nat Commun. 12:5078. PubMed
  710. Yao X, et al. 2022. Nat Commun. 13:3883. PubMed
  711. Tasdemir-Yilmaz OE, et al. 2021. Dev Cell. 56:2516. PubMed
  712. Dudok J, et al. 2016. Neurosci Res. S0168-0102(16)00002-X. PubMed
  713. Rooney G, et al. 2016. J Neurosci. 36: 142 - 152.. PubMed
  714. Takeo Y, et al. 2016. Sci Rep. 6: 25180. PubMed
  715. Okamoto-Uchida Y, et al. 2016. Sci Rep. 6:37697. PubMed
  716. Wang H, et al. 2017. J Neurochem. 141:347. PubMed
  717. Arber C, et al. 2020. Mol Psychiatry. 25:2919. PubMed
  718. Dementyeva EV, et al. 2021. Stem Cell Research. 53:102348. PubMed
  719. Hung C, et al. 2021. Cell Reports. 35(11):109259. PubMed
  720. Cartoni R, et al. 2016. Neuron. 92(6):1294-1307. PubMed
  721. Schoger E, et al. 2021. Stem Cell Research. 55:102473. PubMed
  722. Valdez C, et al. 2020. Hum Mol Genet. 716:29. PubMed
  723. Tolomeo AM, et al. 2021. Front Cell Neurosci. 602888:15. PubMed
  724. Ornaghi F, et al. 2020. Neurobiol Dis. 134:104667. PubMed
  725. Hindman HB, et al. 2019. Exp Eye Res. 181:49. PubMed
  726. Aravamudhan P, et al. 2020. PLoS Pathog. 16:e1008380. PubMed
  727. Medeiros CS, et al. 2018. J Refract Surg. 34:790. PubMed
  728. Romer–Seibert JS, et al. 2019. FASEB J. 33:3291. PubMed
  729. Cotton JL et al. 2017. Developmental cell. 43(1):35-47 . PubMed
  730. Lin B et al. 2017. Cell stem cell. 21(6):761-774 . PubMed
  731. Richard E et al. 2018. Stem cell research. 29:143-147 . PubMed
  732. Kano M, et al. 2019. Endocrinology. 160:1701. PubMed
  733. Schreurs RRCE, et al. 2019. Immunity. 50:462. PubMed
  734. Ioannou MS et al. 2019. Curr Protoc Cell Biol. 84(1):e95 . PubMed
  735. Poulopoulos A, et al. 2019. Nature. 565:356. PubMed
  736. Sun Z, et al. 2019. Nat Commun. 10:3892. PubMed
  737. Ding D, et al. 2018. J Otol. 13:115. PubMed
  738. Fan L et al. 2018. eLife. 7 pii: e35242. PubMed
  739. Amrita Pathak et al. 2018. Developmental cell. 46(3):376-387 . PubMed
  740. Marlier Q et al. 2018. Cell Death Discov. 4:43 . PubMed
  741. Vicentini FA, et al. 2021. Microbiome. 9:210. PubMed
  742. Díaz-García S, et al. 2021. Acta Neuropathol. 142:985. PubMed
  743. Harbuzariu A, et al. 2022. iScience. 25:104407. PubMed
  744. Karpinski BA, et al. 2022. Dis Model Mech. 15:. PubMed
  745. Cai T, et al. 2021. Cell Reports. 36(2):109337. PubMed
  746. van Helden RWJ, et al. 2021. Stem Cell Research. 53:102374. PubMed
  747. Calado SM, et al. 2021. Stem Cell Research. 53:102302. PubMed
  748. Sepehrimanesh M, et al. 2020. American Journal of Physiology-Cell Physiology. 319(4):C771-C780. PubMed
  749. Li C, et al. 2020. eLife. 9:00. PubMed
  750. Fame R, et al. 2016. J Neurosci. 36: 6403 - 6419. PubMed
  751. Long K, et al. 2016. Nat Commun. 7:10354. PubMed
RRID
AB_2728521 (BioLegend Cat. No. 801213)
AB_2313773 (BioLegend Cat. No. 801201)
AB_10063408 (BioLegend Cat. No. 801202)
Disclaimer

Covered by US patents 5,675,063 and 7,429,487. Sold under license from Epitomics.

Antigen Details

Structure
Tubulin β 3 is a 450 amino acid protein with a molecular mass of ~50 kD.
Distribution

Tissue distribution: central and peripheral nervous system.
Cellular distribution: cytosol, cytoskeleton and nucleus.

Function
Tubulin β 3 is the major constituent of microtubules, and plays a critical role in proper axon guidance and maintenance.
Interaction
Alpha tubulin, kinesin and dynein.
Cell Type
Mature Neurons, Neural Stem Cells
Biology Area
Cell Biology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
Microtubules
Antigen References

1. Zhao X, et al. 2017. Med Sci Monit. 22: 3915.
2. Lebok P, et al. 2016. Oncol Lett. 11(3):1987.
3. Du J, et al. 2015. BMC Cancer. 15:536. PubMed
4. Rogue DM., et al. 2013. Clin Exp Metastasis. 31(1): 101.
5. Ploussard G, et al. 2010. Cancer Res. 70(22):9253. PubMed

Gene ID
10381 View all products for this Gene ID
UniProt
View information about Tubulin beta-3 on UniProt.org

Related FAQs

If an antibody clone has been previously successfully used in IBEX in one fluorescent format, will other antibody formats work as well?

It’s likely that other fluorophore conjugates to the same antibody clone will also be compatible with IBEX using the same sample fixation procedure. Ultimately a directly conjugated antibody’s utility in fluorescent imaging and IBEX may be specific to the sample and microscope being used in the experiment. Some antibody clone conjugates may perform better than others due to performance differences in non-specific binding, fluorophore brightness, and other biochemical properties unique to that conjugate.

Will antibodies my lab is already using for fluorescent or chromogenic IHC work in IBEX?

Fundamentally, IBEX as a technique that works much in the same way as single antibody panels or single marker IF/IHC. If you’re already successfully using an antibody clone on a sample of interest, it is likely that clone will have utility in IBEX. It is expected some optimization and testing of different antibody fluorophore conjugates will be required to find a suitable format; however, legacy microscopy techniques like chromogenic IHC on fixed or frozen tissue is an excellent place to start looking for useful antibodies.

Are other fluorophores compatible with IBEX?

Over 18 fluorescent formats have been screened for use in IBEX, however, it is likely that other fluorophores are able to be rapidly bleached in IBEX. If a fluorophore format is already suitable for your imaging platform it can be tested for compatibility in IBEX.

The same antibody works in one tissue type but not another. What is happening?

Differences in tissue properties may impact both the ability of an antibody to bind its target specifically and impact the ability of a specific fluorophore conjugate to overcome the background fluorescent signal in a given tissue. Secondary stains, as well as testing multiple fluorescent conjugates of the same clone, may help to troubleshoot challenging targets or tissues. Using a reference control tissue may also give confidence in the specificity of your staining.

How can I be sure the staining I’m seeing in my tissue is real?

In general, best practices for validating an antibody in traditional chromogenic or fluorescent IHC are applicable to IBEX. Please reference the Nature Methods review on antibody based multiplexed imaging for resources on validating antibodies for IBEX.

Go To Top Version: 7    Revision Date: 01/24/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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