|Amyloid beta deposits can often trigger an innate immune response from microglia. This inflammatory process leads to IL-1β activation and the formation of inflammasomes. Following inflammasome formation, ASC specks can be created and released from the cell. Venegas et al. investigated the ability of ASC specks to promote amyloid beta aggregation and spreading, linking inflammasome activity with Alzheimer's disease progression.
BioLegend provides direct conjugates and purified versions of trusted clones to examine microglia, inflammasomes, and amyloid beta in the advancement of Alzheimer's disease research.
Adapted from Venegas, C. et al. 2017. Nature. 552:355. Pubmed