- Tau 12 (See other available formats)
- Regulatory Status
- Other Names
- PHF-tau, paired helical filament-tau, neurofibrillary tangle protein, microtubule-associated protein tau, isoform 4, G protein beta1/gamma2 subunit-interacting factor 1, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND
Signet Catalog# 9416-02
Signet Catalog# 9416-05
Signet Catalog# 9416-10
Covance Catalog# SIG-39416
- Mouse IgG1
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- Product Citations
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Tau protein promotes microtubule assembly and stability. Tau is abundant in neurons of the central nervous system, and is expressed at low levels in astrocytes and oligodendrocytes. Abnormal hyper-phosphorylation, aggregation, and toxic gain of function of tau is associated with several neurological disorders, including Alzheimer’s disease (AD). The major building block of neurofibrillary lesions in AD brains consists of paired helical filaments (PHFs) of abnormally hyperphosphorylated tau. Six isoforms of tau are generated by alternative splicing of the MAPT gene. These isoforms are distinguished by the number of tubulin binding domains, 3 (3R) or 4 (4R), in the C-terminal of the protein and by one (1N), two (2N), or no (0N) inserts in the N-terminal domain. Tau isoforms are differentially expressed during development.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution (no preservatives or carrier proteins).
- The antibody was purified by affinity chromatography.
- 1 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
WB - Quality tested
IHC-P, ELISA - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.01 - 0.05 µg per ml. For immunohistochemistry, a concentration range of 0.01 - 0.05 µg/ml is suggested. For ELISA applications, a concentration range of 10 - 100 ng/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is specific for an epitope that lies between amino acids 6-18 of human Tau.
(PubMed link indicates BioLegend citation)
- Irwin D, et al. 2012. Brain. 135(Pt 3):: 807. (IHC-P) PubMed
- Horowitz PM, et al. 2004. J Neurosci. 24(36):7895 (WB)
- Sengupta U, et al. 2017. Ann Clin Transl Neurol. 4(4):226. (WB) PubMed
- Meredith JE, et al. 2013. PLoS One. 7;8(10):e76523 (ELISA, WB) PubMed
- Song L, et al. 2015, Mol Neurodegener. 10:14 (ELISA, WB) PubMed
- Product Citations
AB_2715842 (BioLegend Cat. No. 806503)
AB_2564707 (BioLegend Cat. No. 806501)
AB_2564708 (BioLegend Cat. No. 806502)
- Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.
- Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- Tau interacts with: Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Antigen References
1. Meredith JE Jr, et al. 2013. PLoS One. 8(10): e76523. PubMed
2. Goodall CA, et al. 2006. J. Neurol. Neurosurg. Psychiatry 77(1): 89. PubMed
3. Wang Y, Mandelkow E. 2016. Nat. Rev. Neurosci. 17(1):5-21. PubMed
- Gene ID
- 4137 View all products for this Gene ID
- View information about Tau, 6-18 on UniProt.org
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