- A17158D (See other available formats)
- Regulatory Status
- Other Names
- RAGE, AGER, Advanced glycosylation end product-specific receptor
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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RAGE (receptor for advanced glycation end products), is a member of the immunoglobulin super family of proteins with a molecular weight estimated at ~35 kD. RAGE is a pattern recognition receptor as it recognizes a common structure of a class of ligands, including HMGB1, S10012, S100B, S100A7, and amyloid precursor protein (APP). RAGE may play a role in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). Increased RAGE expression levels have been observed in neurons and microglia surrounding senile plaques. In addition, RAGE can mediate the transport of amyloid beta across the blood-brain barrier and its accumulation in the brain.Product Details
- Antibody Type
- Host Species
- Recombinant Human RAGE
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2783446 (BioLegend Cat. No. 855901)
AB_2783447 (BioLegend Cat. No. 855902)
- RAGE is a 404 amino acid protein with an apparent molecular mass of ~43 kD.
Tissue Distribution: Lung (major) and colon (less expressed)
Cellular Distribution: Plasma membrane, extracellular, and nucleus
- Functions as a pattern recognition receptor in the innate immune system that initiates proinflammatory responses.
- RAGE forms homo-dimers, and interacts with HMGB1, S100A1, APP, S100B, S100A12, and S100A14.
- AGEs (advanced glycation end-products)
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Antigen References
- Barbezier N, et al. 2014. Ann. Biol. Clin. (Paris) 72:669.
- Kalea AZ, et al. 2009. Clin. Sci. (Lond) 116:621.
- Gene ID
- 177 View all products for this Gene ID
- View information about RAGE on UniProt.org
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