- Poly28611 (See other available formats)
- Regulatory Status
- Other Names
- PRDX2, Peroxiredoxin-2, Thioredoxin peroxidase 1
- Rabbit Polyclonal IgG
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- Product Citations
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Human peroxiredoxin 2 is encoded by the PRDX2 gene and belongs to one of six peroxiredoxin families including PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6. Peroxiredoxins are expressed ubiquitously and serve as thiol-specific antioxidant enzymes that regulate the redox state, and reduce H2O2 and lipid peroxides. The antioxidative function of peroxiredoxin 2 protects cells from peroxide-induced apoptosis. Peroxiredoxin 2 is also involved in immune regulation. TNF-α- or lipopolysaccharides-induced peroxiredoxin 2 released by macrophages leads to IL-8 production and proinflammatory responses. In the post-ischemic brain, the extracellular release of peroxiredoxin 2 from necrotic brain cells elicits neuronal cell death mediated by macrophage TLR signaling.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant human PRDX2 (amino acid sequence Ala6~Tyr164)
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 1.0 µg/ml for chromogenic staining and 1.0 - 5.0 µg/ml for fluorescent staining is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2814586 (BioLegend Cat. No. 861101)
- Peroxiredoxin 2 is a 198 amino acid protein with predicted and observed molecular mass of ~22 kD.
Tissue Distribution: Predominantly expressed in the liver, lung, kidney, and brain
Cellular Distribution: Cytosol
- Peroxiredoxin 2 protects cells from oxidative stress and functions as a mediator of immune response.
- Peroxiredoxin 2 forms homodimers and a ring-like decamers. It also interacts with TIPIN.
- Cell Type
- Macrophages, Mature Neurons, Neurons
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Proliferation and Viability, Neuroinflammation, Neuroscience
- Molecular Family
- Cytokines/Chemokines, Enzymes and Regulators, Tumor Suppressors
- Antigen References
- Hussain T, et al. 2016. Oxid Med Cell Longev. 7432797.
- Knoops B, et al. 2016. Mol Cells. 39:60.
- Sánchez-Font MF, et al. 2003. Cell Mol Life Sci. 60:1513.
- Gene ID
- 7001 View all products for this Gene ID 21672 View all products for this Gene ID 29338 View all products for this Gene ID
- View information about Peroxiredoxin 2 on UniProt.org
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