- MMp19B2 (See other available formats)
- Regulatory Status
- Other Names
- Interleukin 23 p19/p40, P19, IL-23A, IL23P19
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12.IL-23 is secreted by activated macrophages and dendritic cells.Human and mouse p19 share 70% aa sequence identity. The functional IL-23 receptor complex consists of two receptor subunits, a β1 subunit shared with the IL-12 receptor (IL-12R β1) and a β2-like subunit with STAT4 binding domain, termed the IL-23-specific receptor subunit (IL-23R).IL-23 has been shown to enhance IFN-γ production by memory T cells.Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17.IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse p19 C-terminal peptide
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ELISA Capture - Quality tested
ICC - Verified
Neut - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA capture antibody, a concentration range of 2.0 - 6.0 µg/ml is recommended. To obtain a linear standard curve, serial dilutions of IL-23 recombinant protein ranging from 1000 to 7.8 pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
ELISA Capture: The purified MMP19B2 antibody is useful as a capture antibody for a sandwich ELISA assay, when used in conjunction with the biotinylated C17.8 antibody as detection antibody.
(PubMed link indicates BioLegend citation)
- Keswani T, et al. 2014. Exp Parasitol. 141:82. PubMed
- Product Citations
AB_2233637 (BioLegend Cat. No. 513801)
AB_2280243 (BioLegend Cat. No. 513802)
- Member of the IL-12 cytokine family, heterodimeric cytokine composed of p40 subunit shared with IL-12 and a specific p19 subunit
Secreted by activated dendritic cells and macrophages.
- Upregulated in viral infections, increased in psoriatic lesions and promotes immunity to mycobacteria.
- IL-23 receptor (β1 subunit of IL-12 receptor and IL-23-specific subunit)
- Enhances IFN-γ secretion by memory (CD45RO) T cells and induces unique Th subset (designated Th-17) secreting IL-17.
- Cell Type
- Dendritic cells, Macrophages
- Biology Area
- Molecular Family
- Antigen References
1. Oppmann B, et al. 2000. Immunity 13:715.
2. Parham C, et al. 2002. J. Immunol. 168:5448.
3. Aggarwal S, et al. 2003. J. Biol. Chem. 278:1910.
4. Verreck FA, et al. 2004. Proc. Natl. Acad. Sci. USA 101:4560.
5. Lee E, et al. 2004. J. Exp. Med. 199:125.
- Gene ID
- 83430 View all products for this Gene ID
- View information about IL-23 on UniProt.org
|Purified anti-mouse IL-23 (p19)||MMp19B2||ELISA Capture, ICC, Neut|
|Ultra-LEAF™ Purified anti-mouse IL-23 (p19)||MMp19B2||Neut, ELISA Capture, ICC|
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