Purified anti-mouse CD45RB Antibody

Pricing & Availability
MB4B4 (See other available formats)
Regulatory Status
Other Names
Rat IgG2a, κ
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Product Citations
C57BL/6 mouse splenocytes were stained with purified CD45RB (clone MB4B4, filled histogram) or purified rat IgG2a, κ isotype control (open histogram), followed by anti-rat IgG PE.
  • MB4B4_PURE_CD45RB_Antibody_032816
    C57BL/6 mouse splenocytes were stained with purified CD45RB (clone MB4B4, filled histogram) or purified rat IgG2a, κ isotype control (open histogram), followed by anti-rat IgG PE.
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151602 100 µg 144€
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CD45RB is a 220 kD single chain type I membrane glycoprotein. It is an exon 5 splice variant of the tyrosine phosphatase CD45. The CD45RB isoform is expressed on thymocytes, T cell subsets, B cells, monocytes/macrophages, granulocytes, and dendritic cells. CD45RB plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naïve to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4+ T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
anti-Ig activated murine B cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Birkeland ML, et al. 1988. J. Mol. Cell. Immunol. 4:71.
  2. Birkeland ML, et al. 1989. Proc. Natl. Acad. Sci. USA 86:6734.
  3. Lazarovits AI, et al. 1999. Kidney Int. 55:1303.
AB_2572032 (BioLegend Cat. No. 151602)

Antigen Details

Tyrosine phosphatases, type I transmembrane, 220 kD (exon 5 splicing of CD45 gene).

Thymocytes, T cell subset, B cells, monocytes/macrophages, granulocytes, and dendritic cells.

Enhances TCR and BCR signaling.
Galectin-1, CD2, CD3, and CD4.
Cell Type
Thymocytes, T cells, B cells, Monocytes, Macrophages, Dendritic cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Inhibitory Molecules
Molecular Family
CD Molecules
Antigen References

1. Lee KM, et al. 2014. Cell Transplant. 23:51.
2. Kamanaka M, et al. 2011. J. Exp. Med. 208:1027.
3. Gagliani N, et al. 2011. PLoS One 6(12):e28434.
4. Ten Hove T, et al. 2004. J. Leuko. Biol. 75:1010.
5. Ogilvy S, et al. 2003. J. Immunol. 171:1792.

Gene ID
19264 View all products for this Gene ID
View information about CD45RB on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 03/28/2016

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • PE anti-mouse CD45RB

  • Purified anti-mouse CD45RB

  • FITC anti-mouse CD45RB


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