- RMT1-4 (See other available formats)
- Regulatory Status
- Other Names
- T cell immunoglobulin and mucin domain containing protein-1, T cell and airway phenotype regulator (Tapr), hepatitic virus cellular receptor 1, CD365
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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CD365 (Tim-1) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-1 and hepatitis virus cellular receptor 1. It is developmentally expressed at high levels in the blastocyst. Tim-1 is expressed on activated CD4+ lymphocytes especially on Th2 cells and has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation. Tim-1 is an endogenous ligand for LMIR5/CD300b.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Meyers JH, et al. 2005. Nat. Immunol. 6:455.
- Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800.
- Yamanishi Y, et. al. 2010. J. Exp. Med. 207:1501. (FC)
- Namavari A, et al. 2012. Invest Ophthalmol Vis Sci. 53:4575. PubMed.
- Product Citations
AB_345368 (BioLegend Cat. No. 119502)
- Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD.
Developmentally regulated; highly expressed in embryonic development in blastocysts. Expressed on activated CD4+ lymphocytes, especially Th2 cell lines.
- Binds hepatitis virus, may play a critical role in immune responses and the development of atopic diseases (in particular airway hyperreactivity).
- Binds hepatitis A virus in humans, Tim-4, LMIR5/CD300b
- Cell Type
- T cells, Th2
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. McIntire JJ, et al. 2001. Nature Immunol. 2:1109.
2. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
3. Wills-Karp M, et al. 2001. Nat. Rev. Immunol. 1:69.
4. Meyers JH, et al. 2005. Nat. Immunol. 6(5):455.
- Gene ID
- 171283 View all products for this Gene ID
- View information about CD365 on UniProt.org
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