- 8C6 (See other available formats)
- Other Names
- LIM and SH3 domain protein 1, MLN 50, metastatic lymph node gene 50 protein
Covance Catalog# MMS-426P
- Mouse IgG1
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- Product Citations
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Lasp-1 (LIM and SH3 domain protein 1) is an actin-binding phosphoprotein expressed in a wide range of cell types rich in F-actin. Lasp-1 is believed to play a role in the reorganization of the actin cytoskeleton, and localizes to sites of cytoskeletal assembly in response to signalling inputs. Lasp-1 binding partners, in addition to actin, include the endocytic proteins dynamin 2, Hip1r and clathrin, and proteins involved in focal adhesion including zyxin and krp1. The functions of Lasp-1 protein are not well defined, but evidence suggests roles in cell migration, tumor formation, and membrane remodeling in the regulation of ion transport.Product Details
- Human, Mouse, Rat, Rabbit
- Antibody Type
- Host Species
- Clone 8C6 was raised against a KLH-coupled peptide from a conserved region of LASP-1.
- The antibody was purified by affinity chromatography.
- 1 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
IHC - Quality tested
WB, ICC - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemistry. For immunohistochemistry, a dilution range of 1:100 - 1:200 is suggested. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml (1:1000 - 1:2000 dilution). For immunocytochemistry, a concentration of 10.0 μg/ml (1:100 dilution) is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is effective in immunoblotting (WB) and immunohistochemistry (ICC).
Predicted MW = 37 kD; Positive Control: MDCK cell lysate
(PubMed link indicates BioLegend citation)
- Zhang H, et al. 2009. Physiol Genomics. 38:372. (WB, IF)
- Chew CS, et al. 2008. Am J Physiol Gastrointest Liver Physiol. 295:G37. (WB, IF)
- Chew CS, et al. 2000. J Cell Sci. 113:2035.
- Product Citations
AB_2565095 (BioLegend Cat. No. 909301)
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