- MHJ2-523 (See other available formats)
- Regulatory Status
- Other Names
- Jag2, Jagged-2
- Mouse IgG1, κ
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- Product Citations
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The binding of Notch ligands with their receptors results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect target cells. The Jagged-2 is one of the several Notch ligands identified. It is a single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL (Delta-Serrate-Lag-2) domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). Jagged 2 is expressed on lymphoma cells and some other tumor cells. Jagged-2 is reported to be essential for the regulation of spermatogenesis. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate, T cells and B cells to differentiate.Product Details
- Antibody Type
- Host Species
- Human Jagged2-transfected CHO cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2028550 (BioLegend Cat. No. 346902)
- A single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD).
Expressed on lymphoma cells and some other tumor cells.
- Regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development.
- Notch molecules
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity
- Antigen References
1. Moriyama Y et al. 2008. Int J. Immunol. 20:763
2. Ehebauer MT. et al. 2006. Biochem J 392:13
3. Shimizu K et al. 2000. Mol Cell Biology 20:18
4. Hellstrom M et al. 2007. Nature 445:776
5. Luo B et al. 1997. Mol Cell Biol. 17:6057
6. Stanley P et al. 2009. Immunol. Rev. 230(1):201
- Gene ID
- 3714 View all products for this Gene ID
- View information about Jagged 2 on UniProt.org
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