- S7.7 (See other available formats)
- Other Names
- QA79 membrane protein, Adhesion inhibitory receptor molecule 1, p75/AIRM1, D-siglec
- Mouse IgG1, κ
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- Product Citations
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Siglec-7 is a 75 kD type I transmembrane protein and a member of the family of sialic acid-binding immunoglobulin-like lectins (Siglecs), also known as p75/AIRM1. It is primarily found on NK cells and monocytes. The cytoplasmic domain of Siglec-7 contains immunoreceptor tyrosine-based inhibitory motif (ITIM). CD328 mediates sialic acid-dependent cell-cell binding and functions as an inhibitory receptor of NK cells. CD328 preferentially binds to sialylated glycans with α2,8 disialyl and α2,6 sialyl residues.Product Details
- Antibody Type
- Host Species
- Siglec-7 3T3 transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Nicoll G, et al. 1999. J. Biol Chem. 274:34089.
AB_2189411 (BioLegend Cat. No. 347702)
- Type I transmembrane protein, Siglec family member, 75 kD
Monocytes, NK cells
- Inhibitory receptor of NK cells
- After tyrosine phosphorylation interacts with PTPN6 and SHP-1
- Sialylated glycans (with α,8 disialyl and α2,6 sialyl residues)
- Inhibition of signal transduction by recruiting cytoplasmic phosphatases
- Cell Type
- Monocytes, NK cells
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules, Siglec Molecules
- Antigen References
1. Avril T, et al. 2006. Infect Immun. 74:4133.
2. Avril T, et al. 2006. J. Leukoc. Biol. 80:787.
3. Orr SJ, et al. 2007. J. Biol Chem. 282:3418.
4. Brunetta E, et al. 2009. Blood 114:3822.
- Gene ID
- 27036 View all products for this Gene ID
- View information about CD328 on UniProt.org
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