- 14H4 (See other available formats)
- Regulatory Status
- Other Names
- Neuropilin 1
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
|Cat #||Size||Price||Quantity Check Availability||Save|
The membrane isoform of CD304 is a receptor that regulates angiogenesis and organogenesis in response to growth factors of the VEGF family. CD304 forms a complex with VEGFR2/KDR, resulting in increased cell migration and chemotaxis. In the nervous system, CD304 complexed with plexin mediates Sema-3A signaling and may be involved in axon guidance.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- 293E expressed human CD304 recombinant protein, b isoform
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel (1 µg/ml). It is recommended that the reagent be titrated for optimal performance for each application.
AB_11203372 (BioLegend Cat. No. 652302)
- Single-pass type I membrane protein, 103 kD. Contains two CUB motifs, domains similar to coagulation factors V and VIII, and a MAM domain in the extracellular domain. Isoform b is a soluble form.
Membrane, Secreted (isoform b).
- CD304 is a VEGF co-receptor involved in axon guidance, angiogenesis. and development of cardiovascular system. The secreted isoform inhibits binding of VEGF-165 to cells.
- CD304 is a receptor for members of VEGF family and pro-angiogenesis cytokines, such as VEGF-A165, VEGF-B, VEGF-E, and PIGF-2.
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Signal Transduction
- Molecular Family
- CD Molecules
- Antigen References
1. Soker S, et al. 1998. Cell 92:735.
2. Shintani Y, et al. 2006. EMBO J. 25:3045.
3. He Z, et al. 1997. Cell 90:739.
4. Gagnon ML, et al. 2000. P. Natl. Acad. Sci. USA 97:2573.
5. Glinka Y, et al. 2011. Carcinogenesis 32:613.
- Gene ID
- 8829 View all products for this Gene ID
- View information about CD304 on UniProt.org
|Purified anti-human CD304||14H4||WB|
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.