- MAT3-4G10/8 (See other available formats)
- Regulatory Status
- Other Names
- ATM Serine/Threonine Kinase, Ataxia Telangiectasia Mutated, Serine-Protein Kinase ATM
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that plays a critical role in cell cycle checkpoints and DNA repair. ATM is normally maintained as an inactive dimer in unstressed cells. Cellular irradiation and other genotoxic events that lead to double-stranded DNA breaks induce a rapid intermolecular autophosphorylation of serine 1981 that results in dimer dissociation and initiation of intrinsic kinase activity. ATM serine 1981 phosphorylation is considered a powerful surrogate of both ATM activation and double-stranded DNA break repair. ATM directly regulates a broad range of substrate proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair, including tumor suppressor proteins p53 and BRCA1, and the checkpoint kinase Chk2.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Synthetic mouse ATM peptide
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IP - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.125 - 1.0 µg/mL. For immunoprecipitation, the suggested use of this reagent is 2.0 µg/test. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone was not tested for ICC due to the detection of proteins of unknown origin by western blot.
AB_2876766 (BioLegend Cat. No. 939301)
AB_2876766 (BioLegend Cat. No. 939302)
- ATM is 3056 amino acids protein with a predicted molecular weight of ~351 kD.
Ubiquitously expressed, nuclear
- Serine, threonine kinase, DNA repair and checkpoint signaling
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, DNA Repair/Replication
- Antigen References
1. Lee JH and Paull TT. 2007. Oncogene. 26:7741.
2. Bakkenist CJ and Kastan MB. 2003. Nature. 421:499.
3. McConville CM, et al. 1996. Am. J. Hum. Genet. 59:320.
4. Tang X, et al. 2008. Mol. Cell Biol. 28:2559.
- Gene ID
- 472 View all products for this Gene ID
- View information about ATM on UniProt.org
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