PE anti-mouse CD95 (Fas) Antibody

Pricing & Availability
Clone
SA367H8 (See other available formats)
Regulatory Status
RUO
Other Names
Fas, ALPS1A, APO-1, APT1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
SA367H8_PE_CD95_Antibody_121416
C57BL/6 thymocytes were stained with CD95 (clone SA367H8) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
  • SA367H8_PE_CD95_Antibody_121416
    C57BL/6 thymocytes were stained with CD95 (clone SA367H8) PE (filled histogram) or mouse IgG1, κ PE isotype control (open histogram).
See PE spectral data
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152607 25 µg 152,00€
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152608 100 µg 440,00€
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Description

CD95, also known as Fas, is an approximately 45 kD type I transmembrane protein belonging to the TNFR superfamily (TNFRSF6). The expression of CD95 has been described in various organs, such as  thymus, spleen, liver, heart, lung and ovary. Upon ligand (FasL) binding, CD95 forms the death-inducing signaling complex (DISC) intracellularly and induce apoptosis of the cell. CD95-induced apoptosis plays important roles in development, as well as in maintining peripheral tolerance of the immune system.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Mouse Fas Transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Wang J, et al. 2018. Front Immunol. 9:371. PubMed
  2. Beloor J et al. 2018. Cell host & microbe. 23(4):549-556 . PubMed
  3. Chen S, et al. 2018. Nat Commun. 9:5298. PubMed
  4. Pobezinskaya EL et al. 2019. Front Immunol. 1.079861111 . PubMed
  5. Kim CJ, et al. 2018. Immunity. 49:1034. PubMed
  6. Woodruff MC et al. 2018. Cell reports. 25(2):321-327 . PubMed
  7. Trittel S, et al. 2019. Sci Rep. 9:16362. PubMed
  8. Dheilly E, et al. 2020. Cancer Cell. 37(5):674-689. PubMed
  9. Zhang YN, et al. 2020. EBioMedicine. 56:102819. PubMed
  10. Huang WC, et al. 2020. Adv Mater. 32:e2005637. PubMed
  11. Dumitrescu M, et al. 2020. Int J Mol Sci. 21:00. PubMed
  12. Lazarian G, et al. 2021. Cancer Cell. 39(3):380-393.e8. PubMed
  13. Mandal RK, et al. 2021. Cell Reports. 35(6):109094. PubMed
RRID
AB_2632903 (BioLegend Cat. No. 152607)
AB_2632902 (BioLegend Cat. No. 152608)

Antigen Details

Structure
CD95 (Fas) is an approximately 45 kD type I transmembrane protein; cystiene-rich domain, death domain.
Distribution

Thymus, spleen, liver, heart, lung, and ovary.

Function
Induction of apoptosis.
Interaction
Caspase 8, caspase 10, CFLAR, FADD, PDCD6, SUMO1, and TNFRSF6.
Ligand/Receptor
FasL.
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References

1. Ogasawara J, et al. 1995. J. Exp. Med. 181:485.
2. Ogasawara J, et al. 1993. Nature. 364:806.
3. Nishimura Y, et al. 1995. J. Immunol. 154:4395.

Gene ID
14102 View all products for this Gene ID
UniProt
View information about CD95 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 12/15/2016

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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