APC anti-rat CD161 Antibody

Pricing & Availability
Clone
3.2.3 (See other available formats)
Other Names
NKR-P1, CD161a/CD161b, NKR-P1a/KLRB1a
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
3.2.3_APC_010412
Lewis rat splenocytes were stained with CD161 (clone 3.2.3) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
  • 3.2.3_APC_010412
    Lewis rat splenocytes were stained with CD161 (clone 3.2.3) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
See APC spectral data
Cat # Size Price Quantity Avail. Save
205606 100 µg 312€
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Description

CD161 is a 30 kD type II transmembrane C-type lectin, expressed as a homodimer. Rat NKR-P1 receptors are primarily expressed on NK cells, a subset of T cells, dendritic cells, and activated monocytes. There are three different types of NKR-P in rat, namely NKR-P1a, NKR-P1b, and NKR-P1c. NKR-P1a does not contain an ITIM structure and is an activating receptor, while NKR-P1b contains an ITIM and displays inhibitory function. LLT-1 (ligand lectin like transcript 1) is the ligand, while KLR (killer cell lectin like) functions as a receptor.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
LEW rat splenic NK cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

3.2.3 recognizes a common epitope of NKR-1P1a (CD161a) and NKR-P1b (CD161b).

Application References

(PubMed link indicates BioLegend citation)
  1. Chambers W, et al. 1989. J. Exp. Med. 169:1373. (FC)
Product Citations
  1. Chen C, et al. 2018. J Neuroinflammation. 15:167. PubMed
  2. Ruppert KA, et al. 2018. Sci Rep. 8:480. PubMed
RRID
AB_11142680 (BioLegend Cat. No. 205606)

Antigen Details

Structure
Type II transmembrane C-type lectin, 30 kD.
Distribution
NK cells, subset of T cells, dendritic cells, activated monocytes.
Function
NKR-P1a is a NK cell-activating receptor; NKR-P1b is a NK cell-inhibitory receptor.
Ligand/Receptor
LLT1-ligand lectin like transcript 1; KLR-killer cell lectin like receptor.
Cell Type
NK cells, T cells, Dendritic cells, Monocytes
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Chambers WH, et al. 1989. J. Exp. Med. 169:1373.
2. Brink M, et al. 1990. J. Exp. Med. 171:197.
3. Li J, et al. 2003. Int. Immunol. 15:411.

Gene ID
362443 View all products for this Gene ID
UniProt
View information about CD161 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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