- 590H11G1E3 (See other available formats)
- Regulatory Status
- Other Names
- C-Mer Proto-Oncogene Tyrosine Kinase, c-mer, Proto-Oncogene C-Mer, MER Receptor Tyrosine Kinase, STK Kinase, Receptor Tyrosine Kinase MerTK, Tyrosine-Protein Kinase Mer, MER, RP38, c-Eyk, Tyro12
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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MERTK plays a role in the retinal pigment epithelium as a regulator of rod outer segments fragments phagocytosis. MERTK also plays a role in the inhibition of Toll-like receptor-mediated innate immune responses through the activation of STAT1. Upregulation of MERTK seems to also promote the survival of certain cancer cells, such as t(1;19)-positive acute lymphoblastic leukemias (ALL). MERTK also has a role in cellular migration, as MERTK KO macrophages demonstrate cytoskeletal disruptions that impacts its shape and directional migration. Melanoma cells express high levels of MERTK, which makes this molecule an attractive therapeutic target.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- MERTK extracellular domain/Fc fusion.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Rogers AE, et al. 2012. Oncogene 31:4171.
AB_2687288 (BioLegend Cat. No. 367611)
AB_2687289 (BioLegend Cat. No. 367612)
- Transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain.
Macrophages, monocytes, and dendritic cells.
- TLR regulation, efferocytosis, phagocytosis regulation, cell survival, and macrophage migration.
- GRB2, PLCG2, and TNK2.
- LGALS3, TUB, TULP1, and GAS6.
- Cell Type
- Dendritic cells, Macrophages, Monocytes
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Motility/Cytoskeleton/Structure, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Protein Kinases/Phosphatase, Toll Like Receptors
- Antigen References
1. Schlegel J, et al. 2013. J. Clin. Invest. 123:2257.
2. Chen J, et al. 1997. Oncogene 14:2033.
3. Yefimova MG, et al. 2013. Autophagy 9:653.
4. Zhang W, et al. 2013. J. Med. Chem. 56:9693.
5. Lee YJ, et al. 2012. J. Leuko. Biol. 91:921.
6. Krause S, et al. 2015. Blood 125:820.
7. Tang Y, et al. 2015. PLoS One 10:e0117787.
- Gene ID
- 10461 View all products for this Gene ID
- View information about MERTK on UniProt.org
|Purified anti-human MERTK||590H11G1E3||FC|
|Brilliant Violet 421™ anti-human MERTK||590H11G1E3||FC|
|Alexa Fluor® 647 anti-human MERTK||590H11G1E3||FC|
|PE anti-human MERTK||590H11G1E3||FC|
|APC anti-human MERTK||590H11G1E3||FC|
|PE/Cyanine7 anti-human MERTK||590H11G1E3||FC|
|APC/Fire™ 750 anti-human MERTK||590H11G1E3||FC|
|Biotin anti-human MERTK||590H11G1E3||FC|
|TotalSeq™-A0423 anti-human MERTK||590H11G1E3||PG|
|Brilliant Violet 711™ anti-human MERTK||590H11G1E3||FC|
|PerCP/Cyanine5.5 anti-human MERTK||590H11G1E3||FC|
|TotalSeq™-C0423 anti-human MERTK Antibody||590H11G1E3||PG|
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Purified anti-human MERTK
Brilliant Violet 421™ anti-human MERTK
Alexa Fluor® 647 anti-human MERTK
PE anti-human MERTK
APC anti-human MERTK
PE/Cyanine7 anti-human MERTK
APC/Fire™ 750 anti-human MERTK
Biotin anti-human MERTK
TotalSeq™-A0423 anti-human MERTK
Brilliant Violet 711™ anti-human MERTK
PerCP/Cyanine5.5 anti-human MERTK
TotalSeq™-C0423 anti-human MERTK Antibody