- 1D10B31 (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG2b, κ
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- Product Citations
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IL-31, produced mainly by activated CD4+ T cells, is a newly discovered helical cytokine belonging to the gp130/IL6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Human IL-31 is also involved in inflammatory bowel disease, airway hypersensitivity, and dermatitis.Product Details
- Antibody Type
- Host Species
- Full length human IL-31 recombinant protein expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
AB_2566762 (BioLegend Cat. No. 659605)
AB_2566763 (BioLegend Cat. No. 659606)
- 161 aa with with a putative 23 aa signal peptide that is cleaved to generate a 138 aa mature protein.
- Secreted by activated CD4 T cells.
- IL-31 belongs to the IL-6 family of cytokines and plays a role in skin inflammation.
- Binds to IL-31 receptor complex that consists of two receptor subunits, IL31RA and OSMR.
- Cell Type
- T cells, Eosinophils
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Antigen References
1. McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42.
2. Arai I, et al. 2013. Exp. Dermatol. 22:669.
3. Dai X, et al. 2013. PLoS One. 8:e67666.
4. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446.
5. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232.
6. Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5.
- Gene ID
- 386653 View all products for this Gene ID
- View information about IL-31 on UniProt.org
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