- S18005H (See other available formats)
- Regulatory Status
- Other Names
- FCGR2B, FCgRIIB, FCGR2C, FCRIIC, IGFR2, CD32B, CD32C, FCG2, FCGR2, IGFR2, FcRII-c, CDW32
- Mouse IgG1, κ
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- Product Citations
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CD32B (FCGR2B) and CD32C (FCGR2C) are 40 kDa, type I transmembrane proteins that are members of the Ig superfamily of low-affinity immunoglobulin gamma Fc receptors. CD32B has a cytoplasmic tail that contains an immunoreceptor tyrosine-based inhibition motif (ITIM), while CD32C contains an immunoreceptor tyrosine-based activation motif (ITAM). CD32B and CD32C are low affinity receptor for monomeric IgG but also bind IgG complexes. CD32B and CD32C are expressed on B cells, subsets of monocytes,macrophages and granulocytes, platelets, mast cells, and is a negative regulator of cell activation, proliferation, endocytosis, phagocytosis, and degranulation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633 nm / 635 nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
- Application Notes
As the extracellular region of CD32B and CD32C are identical, this Ab recognizes both isoforms. Does not crossreact with CD32A.
AB_2890841 (BioLegend Cat. No. 398307)
AB_2890841 (BioLegend Cat. No. 398308)
- Type I transmembrane protein, 40 kDa, member of the Ig superfamily
B cells, subsets of monocytes,macrophages and granulocytes, platelets, mast cells.
- Negatively regulates cell activation, proliferation, endocytosis, phagocytosis, and degranulation
- Fc region of complex or aggregated immunoglobulins gamma
- Cell Type
- B cells, Dendritic cells, Granulocytes, Monocytes, Platelets
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Fc Receptors
- Antigen References
- Bruhns P, et al. 2009. Blood. 113: 3716.
- Bewarder N, et al. 1996. Mol Cell Biol. 16: 4735.
- Descours B, et al. 2017. Nature. 543: 564.
- Tomiyama Y, et al. 1992. Blood. 80: 2261.
- Indik Z, et al. 1991. J Clin Invest. 88: 1766.
- Ramsland PA, et al. 2011. J Immunol. 187: 3208.
- Hogarth PM and Pietersz GA. 2012. Nat Rev Drug Discov. 11: 311.
- Bournazos S, et al. 2009. J Immunol. 182: 8026.
- Maxwell KF, et al. 1999. Nat Struct Biol. 6: 437.
- Sandilands GP, et al. 1997. Immunology. 91: 204.
- Ghazizadeh S, et al. 1994. J Biol Chem. 269: 8878.
- Gillis C, et al. 2014. Front Immunol. 5: 254.
- Gene ID
- 2213 View all products for this Gene ID 9103 View all products for this Gene ID
- View information about CD32B CD32C on UniProt.org
|Purified anti-human CD32B/C||S18005H||FC|
|Alexa Fluor® 647 anti-human CD32B/C||S18005H||FC|
|APC anti-human CD32B/C||S18005H||FC|
|Alexa Fluor® 700 anti-human CD32B/C Antibody||S18005H||FC|
|PerCP/Cyanine5.5 anti-human CD32B/C Antibody||S18005H||FC|
|APC/Cyanine7 anti-human CD32B/C Antibody||S18005H||FC|
|PE/Cyanine7 anti-human CD32B/C Antibody||S18005H||FC|
|PE/Dazzle™ 594 anti-human CD32B/C Antibody||S18005H||FC|
|PE anti-human CD32B/C||S18005H||FC|
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human CD32B/C
Alexa Fluor® 647 anti-human CD32B/C
APC anti-human CD32B/C
Alexa Fluor® 700 anti-human CD32B/C Antibody
PerCP/Cyanine5.5 anti-human CD32B/C Antibody
APC/Cyanine7 anti-human CD32B/C Antibody
PE/Cyanine7 anti-human CD32B/C Antibody
PE/Dazzle™ 594 anti-human CD32B/C Antibody
PE anti-human CD32B/C