- S18005H (See other available formats)
- Regulatory Status
- Other Names
- FCGR2B, FCgRIIB, FCGR2C, FCRIIC, IGFR2, CD32B, CD32C, FCG2, FCGR2, IGFR2, FcRII-c, CDW32
- Mouse IgG1, κ
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- Product Citations
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CD32B (FCGR2B) and CD32C (FCGR2C) are 40 kDa, type I transmembrane proteins that are members of the Ig superfamily of low-affinity immunoglobulin gamma Fc receptors. CD32B has a cytoplasmic tail that contains an immunoreceptor tyrosine-based inhibition motif (ITIM), while CD32C contains an immunoreceptor tyrosine-based activation motif (ITAM). CD32B and CD32C are low affinity receptor for monomeric IgG but also bind IgG complexes. CD32B and CD32C are expressed on B cells, subsets of monocytes,macrophages and granulocytes, platelets, mast cells, and is a negative regulator of cell activation, proliferation, endocytosis, phagocytosis, and degranulation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
- Application Notes
As the extracellular region of CD32B and CD32C are identical, this Ab recognizes both isoforms. Does not crossreact with CD32A.
AB_2860998 (BioLegend Cat. No. 398305)
AB_2860999 (BioLegend Cat. No. 398306)
- Type I transmembrane protein, 40 kDa, member of the Ig superfamily
B cells, subsets of monocytes,macrophages and granulocytes, platelets, mast cells.
- Negatively regulates cell activation, proliferation, endocytosis, phagocytosis, and degranulation
- Fc region of complex or aggregated immunoglobulins gamma
- Cell Type
- B cells, Dendritic cells, Granulocytes, Monocytes, Platelets
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Fc Receptors
- Antigen References
- Bruhns P, et al. 2009. Blood. 113: 3716.
- Bewarder N, et al. 1996. Mol Cell Biol. 16: 4735.
- Descours B, et al. 2017. Nature. 543: 564.
- Tomiyama Y, et al. 1992. Blood. 80: 2261.
- Indik Z, et al. 1991. J Clin Invest. 88: 1766.
- Ramsland PA, et al. 2011. J Immunol. 187: 3208.
- Hogarth PM and Pietersz GA. 2012. Nat Rev Drug Discov. 11: 311.
- Bournazos S, et al. 2009. J Immunol. 182: 8026.
- Maxwell KF, et al. 1999. Nat Struct Biol. 6: 437.
- Sandilands GP, et al. 1997. Immunology. 91: 204.
- Ghazizadeh S, et al. 1994. J Biol Chem. 269: 8878.
- Gillis C, et al. 2014. Front Immunol. 5: 254.
- Gene ID
- 2213 View all products for this Gene ID 9103 View all products for this Gene ID
- View information about CD32B CD32C on UniProt.org
|Purified anti-human CD32B/C||S18005H||FC|
|Alexa Fluor® 647 anti-human CD32B/C||S18005H||FC|
|APC anti-human CD32B/C||S18005H||FC|
|Alexa Fluor® 700 anti-human CD32B/C Antibody||S18005H||FC|
|PerCP/Cyanine5.5 anti-human CD32B/C Antibody||S18005H||FC|
|APC/Cyanine7 anti-human CD32B/C Antibody||S18005H||FC|
|PE/Cyanine7 anti-human CD32B/C Antibody||S18005H||FC|
|PE/Dazzle™ 594 anti-human CD32B/C Antibody||S18005H||FC|
|PE anti-human CD32B/C||S18005H||FC|
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human CD32B/C
Alexa Fluor® 647 anti-human CD32B/C
APC anti-human CD32B/C
Alexa Fluor® 700 anti-human CD32B/C Antibody
PerCP/Cyanine5.5 anti-human CD32B/C Antibody
APC/Cyanine7 anti-human CD32B/C Antibody
PE/Cyanine7 anti-human CD32B/C Antibody
PE/Dazzle™ 594 anti-human CD32B/C Antibody
PE anti-human CD32B/C