- 13.14.1 (See other available formats)
- Regulatory Status
- Other Names
- SND1, TDRD11, Staphylococcal nuclease domain-containing protein 1, 100 kD coactivator, p100
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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Tudor-SN, also called SND1 or p100, is a multifunctional protein. It has been identified in mammals, fish, Drosophila, Caenorhabditis elegans, ciliates and fission yeast, but not in bacteria. It was first characterized as a co-activator of Epstein-Barr virus nuclear protein 2, and subsequently found to interact with other transcription factors such as c-Myb, Pim-1, STAT6, and STAT5. Tudor-SN regulates pre-mRNA splicing through interacting with components of the spliceosome. Many studies also demonstrate that Tudor-SN potentially participates in the cell cycle regulation.
Studies have illustrated the significant association of Tudor-SN with different types of cancers, such as liver, breast, prostate and colorectal cancers and malignant glioma. It is overexpressed in these cancers and known to promote carcinogenesis.
- Human, Mouse
- Antibody Type
- Host Species
- C-term region (698-910 a.a.)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
KO/KD-WB - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
- Ota H, et al. 2013. Cell. 153:575.
AB_2629792 (BioLegend Cat. No. 690002)
- 910 amino acid with a predicted molecular weight of 102kD, but can be observed at ~110 kD due to post transitional modifications.
Cytoplasm, nucleus and melanosome.
- Bridging factor between STAT6 and the basal transcription factor; PIM1 regulation of MYB activity; transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2.
- EBNA2, EAV NSP1, GTF2E1, GTF2E2, STAT6, POLR2A and STAT5.
- Biology Area
- Cell Biology, Transcription Factors
- Antigen References
1. Li CL, et al. 2008. Nucleic Acids Res. 36:3579.
2. Caudy AA, et al. 2003. Nature. 425:411.
3. Howard-Till RA, et al. 2007. Cell. 6:1795.
4. Tong X, et al. 1995. Mol. Cell. Biol. 15:4735.
5. Su C, et al. 2015. J. Biol. Chem. 290:7208.
6. Leverson JD, et al. 1998. Mol. Cell. 2:417.
7. Yang J, et al. 2002. EMBO J. 21:4950.
8. Jariwala N, et al. 2015. Int. J. Oncol. 46:465.
- Gene ID
- 27044 View all products for this Gene ID
- View information about Tudor-SN on UniProt.org
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