- N270/47 (See other available formats)
- Regulatory Status
- Other Names
- Synaptotagmin VI, Synaptotagmin 6, SYT6
- Mouse IgG1, κ
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- Product Citations
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Synaptotagmin-6 (SYT6) is a member of the synaptotagmin family, which consists of 13 membrane trafficking proteins that contain a N-terminal transmembrane region, and two cytoplasmic C2 domains. It has been reported that SYT6 plays an important role in Ca2+-dependent exocytosis of secretory vesicles, thus being an essential part of the neurotransmitter release machinery. SYT6 also mediates exocytosis in sperm acrosomal reaction via similar Ca2+-dependent mechanism.Product Details
- Verified Reactivity
- Mouse, Rat
- Antibody Type
- Host Species
- Fusion protein corresponding to amino acids 246-333 (cytoplasmic C2A domain) of mouse Synaptotagmin-6.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The double bands observed in WB may correspond to the phosphorylation status of SYT61.
In-house evaluation shows that this antibody does not work in IHC.
- Application References
- Roggero CM, et al. 2005. Dev. Biol. 285:422-35.
AB_2750179 (BioLegend Cat. No. 853901)
AB_2750180 (BioLegend Cat. No. 853902)
- Synaptotagmine-6 is a 511 amino acid protein with a molecular mass of ~57 kD.
Tissue Distribution: Mainly expressed in the brain (olfactory bulb)
Cellular Distribution: Cytosol and plasma membrane
- SYT6 is involved in Ca2+-dependent exocytosis of secretory vesicles.
- SYT6 forms homodimer and may also form heterodimer with STY3, SYT7, SYT9, and SYT10. SYT6 also interacts with STX1A, STX1B, and STX2.
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology
- Molecular Family
- Presynaptic proteins
- Antigen References
- Mikoshiba K et al. 1999. Chem. Phys. Lipids. 98:59.
- Wong YH, et al. 2015. Proc. Natl. Acad. Sci. USA. 112:E4475.
- Gene ID
- 148281 View all products for this Gene ID 60565 View all products for this Gene ID
- View information about Synaptotagmin-6 on UniProt.org
Related Pages & Pathways
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