- Avas12 (See other available formats)
- Regulatory Status
- Other Names
- Fetal liver kinase 1 (Flk-1), VEGF receptor-2, VEGF-R2, Ly-73, KDR
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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CD309 is also known as vascular endothelial growth factor receptor 2 (VEGFR2) and fetal liver kinase-1 (Flk-1). CD309 is a member of the tyrosine protein kinase family that contains a single pass transmembrane receptor with a protein kinase domain and seven immunoglobulin-like domains in the extracellular region. CD309 is expressed at high levels in adult heart, lung, kidney, brain, and skeletal muscle. It's a receptor for VEGF or VEGFC, and plays an important role in the development of vascular endothelial cells, hematopoietic cells, and vascular permeability.Product Details
- Antibody Type
- Host Species
- Murine Flk1 fused to hIgG Fc
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
WB, IHC-F - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Avas12 recognizes a different epitope than clone 89B3A5. Additional reported applications (for the relevant formats) include: Western blotting1 and immunohistochemical staining of paraformaldehyde-fixed frozen sections2.
- Application References
- Kataoka H, et al. 1997. Dev. Growth Differ. 39:729. (WB)
- Ishitobi H, et al. 2010. Exp. Anim. 59:615. (IHC-F)
- Product Citations
AB_1967098 (BioLegend Cat. No. 136401)
AB_1967090 (BioLegend Cat. No. 136402)
- A receptor protein tyrosine kinase closely related to CD117 (c-kit) and CD140a (PDGF receptor α chain) of the immunoglobulin superfamily
Expressed at high levels in adult heart, lung, kidney, brain, and skeletal muscle
- Plays an important role in the development of vascular endothelial cells, hematopoietic cells, and vascular permeability
- Vascular endothelial growth factor (VEGF)
- Biology Area
- Angiogenesis, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
1. Kaburn N, et al. 1997. Development. 124:2039
2. Patterson C, et al. 1995. J. Bio. Chem. 270:23111
3. Nishikawa SI, et al. 1998. Immunity 8 (6):761
4. Shalaby F, et al. 1997. Cell. 89 (6):981
- Gene ID
- 16542 View all products for this Gene ID
- View information about CD309 on UniProt.org
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