- A15058A (See other available formats)
- Regulatory Status
- Other Names
- Epstein-Barr Virus Induced 3, EBV-Induced Gene 3 Protein, IL-27 Subunit Beta, IL-27B, IL-35 subunit
- Mouse IgG2b, κ
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- Product Citations
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EBI3 is an IL-12 p40-related protein that can be heterodimerized with IL-12 p35 to form IL-35, or with an IL-12 p35-related protein, p28, to form IL-27. It is produced by antigen-presenting cells such as B cells, monocytes, and dendritic cells following stimulation through TLR. EBI3 can regulate T cell differentiation and proliferation. IL-27 and IL-35 are anti-inflammatory cytokines that are able to inhibit Th17 generation, promote Th1 differentiation, and impact B cell differentiation and immunoglobulin production. In addition to this, both IL-27 and IL-35 increase cytolytic activity of CD8+ T cells. IL-35 is also involved in tumorigenesis and is a promising biomarker for assessing tumor progression and prognosis in a clinical setting.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Purified Recombinant Human IL-35-Fc fusion protein expressed in 293E cells.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone A15058A does not react with mouse EBI3.
AB_2572169 (BioLegend Cat. No. 684602)
- 229 amino acids with a predicted molecular weight of approximately 25 kD.
- B cells, monocytes, and dendritic cells.
- Pro- and anti-inflammatory.
- IL-27 p28 subunit and IL-35 p35 subunit.
- WSX-1(TCCR) and gp130.
- Cell Type
- B cells, Monocytes, Dendritic cells
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology, Signal Transduction
- Molecular Family
- Antigen References
1. Pflanz S, et al. 2002. Immunity. 16:779.
2. Takeda A, et al. 2003. J. Immunol. 170:4886.
3. Pflanz S, et al. 2004. J. Immunol. 172:2225.
4. Li MF, et al. 2013. Dev. Comp. Immunol. 41:514.
5. Zeng JC, et al. 2013. Int. J. Clin. Exp. Pathol. 6:1806.
6. Ouyang H, et al. 2014. Am. J. Med. Sci. 348:156.
- Gene ID
- 10148 View all products for this Gene ID
|Purified anti-IL-27/IL-35 EBI3||A15058A||WB|
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