- 7C9 (See other available formats)
- Regulatory Status
- Other Names
- Sialic acid-binding Ig-like lectin 8 (Siglec-8), Siglec8L, Sialoadhesin family member 2 (SAF2)
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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Siglec-8 is a lectin specific for 6'-sulfo-sLex and a member of the Ig-superfamily. It is expressed almost exclusively in eosinophils; however, basophils and mast cells can express it to a lower degree. Siglec-8 is a 54 kD transmembranal protein; the extracellular domain has one V-set Ig-like domain and two C2-set domains. The cytoplasmic domain has two immunoreceptor tyrosine-based inhibitor motifs (ITIM) that recruit SH2-family phosphatases after tyrosine phosphorylation. There are reports that siglec-8 inhibits the release of histamine and prostaglandin D2 mediated by the IgEFcR. This molelcule is also involved in the induction of apoptosis.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant Siglec-8 fused to human IgG Fc
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
- Floyd H, et al. 2000. J. Biol. Chem. 275:861.
- Wen T, et al. 2014. J Immunol. 192:5481. PubMed
- Product Citations
AB_2239311 (BioLegend Cat. No. 347102)
- A lectin of 54 kD, belonging to the Ig-superfamily; has one V-set Ig-like domain and two C2-set domains; has a single transmembrane domain, and two immunoreceptor tyrosine-based inhibitor motifs (ITIM) in the cytoplasmic domain
Eosinophils, basophils, mast cells
- Cell adhesion, signal transduction
- Phosphatases containing a SH2 domain
- Inhibition of IgE receptor-triggered histamine and prostaglandin D2 release, apoptosis
- Cell Type
- Basophils, Eosinophils, Mast cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Signal Transduction
- Molecular Family
- Adhesion Molecules, Siglec Molecules
- Antigen References
1. Bochner BS, et al. 2009. Clin. Exp. Allergy. 39:317.
2. Hudson SA, et al. 2009. J. Pharmacol. Exp. Ther. 330:608.
3. Nutku E, et al. 2005. Biochem. Biophys. Res. Commun. 336:918.
- Gene ID
- 27181 View all products for this Gene ID
- View information about Siglec-8 on UniProt.org
|Purified anti-human Siglec-8||7C9||FC|
|PE anti-human Siglec-8||7C9||FC|
|APC anti-human Siglec-8||7C9||FC|
|PE/Dazzle™ 594 anti-human Siglec-8||7C9||FC|
|PE/Cyanine7 anti-human Siglec-8||7C9||FC|
|PerCP/Cyanine5.5 anti-human Siglec-8||7C9||FC|
|TotalSeq™-C0199 anti-human Siglec-8||7C9||PG|
|PE/Cyanine5 anti-human Siglec-8||7C9||FC|
|TotalSeq™-D0199 anti-human Siglec-8||7C9||PG|
|Biotin anti-human Siglec-8||7C9||FC|
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Purified anti-human Siglec-8
PE anti-human Siglec-8
APC anti-human Siglec-8
PE/Dazzle™ 594 anti-human Siglec-8
PE/Cyanine7 anti-human Siglec-8
PerCP/Cyanine5.5 anti-human Siglec-8
TotalSeq™-C0199 anti-human Siglec-8
PE/Cyanine5 anti-human Siglec-8
TotalSeq™-D0199 anti-human Siglec-8
Biotin anti-human Siglec-8