- BL28630 (See other available formats)
- Regulatory Status
- Other Names
- Zonulin, Alpha Polypeptide, Beta polypeptide, Binding Peptide, HP2ALPHA2, HPA1S, BP, Haptoglobin Alpha(1S)-Beta, Haptoglobin Alpha(2FS)-Beta
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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Haptoglobin is a protein that is mainly expressed by hepatic cells in the liver. Haptoglobin is an acute-phase antioxidant that binds to free hemoglobin (Hb) in the plasma and inhibits the oxidative activity of hemoglobin. Individuals carrying the haptoglobin 2-2 genotype have decreased affinity to Hb and are at a higher risk of developing cerebral aneurysm-related complications due to impaired anti-inflammatory pathways. This highlights haptoglobin as part of the Hb scavenging mechanism, which may be critical for clearing Hb after intracranial bleeding and neuroprotection.Product Details
- Antibody Type
- Host Species
- Recombinant human Haptoglobin corresponding to amino acids 168 – 391 expressed by E.coli.
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 - 5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2814603 (BioLegend Cat. No. 863001)
- Haptoglobin is a 406 amino acid protein with predicted and observed molecular mass of ~45 kD.
Tissue Distribution: Liver and blood plasma
Cellular Distribution: Extracellular and cytosol
- Haptoglobin is a part of the hemoglobin scavenging mechanism that clears Hb released into the central nervous system after intracranial bleeding.
- Haptoglobin forms tetramers of two alpha and two beta chains. It binds to hemoglobin and CD163.
- Biology Area
- Neurodegeneration, Neuroinflammation, Neuroscience
- Molecular Family
- Blood Group Markers
- Antigen References
- Bulters D, et al. 2018. Nat Rev Neurol. 14(7):416.
- Blackburn SL, et al. 2018. Front Physiol. 9:592.
- Bamm VV, et al. 2017. Metab Brain Dis. 32(1):19-34.
- Gene ID
- 3240 View all products for this Gene ID
- View information about Haptoglobin on UniProt.org
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