- Poly28613 (See other available formats)
- Regulatory Status
- Other Names
- Mitochondrial fission 1 protein, FIS1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, TTC11, FIS1 Homolog, Fission, Mitochondrial 1, hFIS1
- Rabbit Polyclonal IgG
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- Product Citations
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Mitochondria are dynamic organelles that vary in copy number, size, and position in any give cell type, often reflecting the energy requirements of the cell. Fusion and Fission is a well conserved and complex process for mitochondria morphology homeostasis, dysfunction of which is linked to many disorders. Human FIS1 protein, a homolog of yeast FIS1p, was identified as a mitochondria outer membrane protein. Overexpression of FIS1 leads to mitochondrial fragmentation and aggregation in mammalian cells caused by excessive fission events. Aberrant mitochondrial fragmentation leads to cytochrome C release and induction of apoptosis. Depletion of Fis1 induces mitochondrial fusion and elongation.Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant FIS1 (Met1-Asp121) expressed in E.coli.
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. For immunohistochemistry, a concentration range of 1.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2810743 (BioLegend Cat. No. 861301)
- Human FIS1 is a 152 amino acid protein with a molecular mass of 17 kD.
Tissue distribution: Ubiquitously expressed
Cellular distribution: Peroxisome and mitochondria
- FIS1 is involved in the fragmentation of the mitochondrial network and its perinuclear patterning.
- Interacts with DNM1L/DLP1, MARCH5, MIEF1, PEX11A, PEX11B, PEX11G.
- Antigen References
- Stojanovski D, et al. 2004. J Cell Sci. 117(Pt 7):1201-10.
- James DI, et al. 2003. J Biol Chem. 278(38):36373-9.
- Gene ID
- 51024 View all products for this Gene ID
- View information about FIS on UniProt.org
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