- 16C12B70 (See other available formats)
- Other Names
- CCAAT/enhancer-binding protein alpha, C/EBP-A
- Mouse IgG2a, κ
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- Product Citations
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The CCAAT-enhancer binding proteins (C/EBP) are members of the basic region/leucine zipper (bZIP) transcription factors, that bind to the consensus CCAAT sequence in DNA. C/EBPα is expressed in two isoforms: p42 and p30 by ultilizing different translational start codons. The C/EBPα p30 isoform has little to no transactivating activity and acts as an inhibitor. C/EBPα regulates expression of various myeloid-specific genes and is required for myeloid differentiation. C/EBPα has been found to play a key role in adipogenesis, since inhibition of C/EBPα blocks adipocyte differentiation. C/EBPα also regulates cell cycle progression through interactions with cyclin-dependent kinases (CDK) and by inducing the expression of CDK inhibitor p21. Mutations in the C/EBPα gene are associated with the development of acute myeloid leukemia.Product Details
- Human, weakly cross-reacts with mouse
- Antibody Type
- Host Species
- Synthetic peptide (AKQLALAGLFPYQPPPP) conjugated to KLH.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IF - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2564224 (BioLegend Cat. No. 662102)
- 358 amino acids with a predicted molecular weight of 38 kD; contains a bZIP domain responsible for DNA binding.
- C/EBPα is a bZIP transcription factor that regulates proliferation and differentiation of myeloid cells and adipocytes.
- C/EBPα forms heterodimers with C/EBPβ and γ; interacts with CDK2, CDK4, PRDM16, UBN1, and ZNF638.
- Cell Type
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Immunology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
1. De Obaldia ME, et al. 2013. Nat. Immunol. 14:1277.
2. Di Tullio A, et al. 2011. Proc. Natl. Acad. Sci. USA. 108:17016.
3. Fan HY, et al. 2011. Mol. Endocrinol. 25:253.
4. Cai DH, et al. 2008. Oncogene. 27:2772.
5. Khanna-Gupta A. 2008. Blood Cells Mol. Dis. 41:77.
6. Janardhan HP. 2008. Sci. Signal. 1:jc2.
- Gene ID
- 1050 View all products for this Gene ID
- View information about C/EBPalpha on UniProt.org
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