- A16 (See other available formats)
- Regulatory Status
- Other Names
- CCAAT/enhancer-binding protein beta, Alpha-1-acid glycoprotein/enhancer binding protein, Interleukin 6-dependent DNA-binding protein (IL-6DBP), Nuclear factor of interleukin 6 (NF-IL6), Liver-enriched transcriptional activator protein (LAP)
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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C/EBPβ (also known as CCAAT/enhancer-binding protein beta, interleukin 6-dependent DNA-binding protein, and nuclear factor of interleukin 6 [NF-IL6]) is a member of the basic leucine zipper C/EBP transcription factor family. Mouse C/EBP has three isoforms that include C/EBPβ-FL, C/EBPβ-LAP, and C/EBPβ-LIP (31kD, 29kD and 16kD, respectively). This protein is localized in the nucleus and functions as a transcription factor in immune, inflammatory, acute-phase, cytokine, collagen type I gene expression. It is upregulated by growth hormones and has been shown to interact with CEBP-α, CEBP-δ, CEBP-γ, CEBP-ε, and CEBP-ζ. The C/EBPβ protein is known to be modified by phosphorylation and ubiquitination. Clone A16 has been shown to be useful for Western blotting to recognize C/EBPβ-FL (31kD) and C/EBPβ-LAP (29kD) isoforms.Product Details
- Mouse (recognizes C/EBPβ-FL (31kD) and C/EBPβ-LAP (29kD) isoforms)
- Antibody Type
- Host Species
- Recombinant full length mouse C/EBP β protein
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
A16 monoclonal antibody recognizes C/EBPß-FL (31kD) and C/EBPß-LAP (29kD) isoforms, but not C/EBPß-LIP (16kD).
- Application References
- Lee YM, et al.1996. Mol. Cell. Biol. 16:4257
- Su, et al. 2003. J. Biol. Chem. 278:51150.
- Product Citations
AB_2097742 (BioLegend Cat. No. 626001)
AB_2097741 (BioLegend Cat. No. 626002)
- C/EBP transcription factor family, basic leucine zipper, dimer. Mouse C/EBP has three isoforms that include C/EBPβ-FL, C/EBPβ-LAP, and C/EBPβ-LIP (31kD, 29kD and 16kD, respectively).
- Transcription factor in immune, inflammatory, acute-phase, cytokine, collagen type I genes
- CEBP-α, CEBP-β, CEBP-δ, CEBP-γ, CEBP-ε, CEBP-ζ
- Phosphorylation, Ubiquitination
- Biology Area
- Cell Biology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
1. Chang C, et al. 1990. Mol. Cell Biol. 10:6642.
2. Eaton E, et al. 2001. J. Cell Physiol. 189:91.
3. Piwien-Pilipuk G, et al. 2002. J. Biol. Chem. 277:44557.
4. Hattori T, et al. 2003. Oncogene. 22:1273.
- Growth hormone
- Gene ID
- 12608 View all products for this Gene ID
- View information about C/EBP beta on UniProt.org
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