- 13F10 (See other available formats)
- Regulatory Status
- Other Names
- Actin-interacting protein 1
- Rat IgG
- Ave. Rating
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- Product Citations
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AIP1(actin-interaction protein 1) is a 67 kD WD repeat protein known to regulate the depolymerization of actin filaments by cofilin and is conserved in organisms ranging from yeast to mammals. Recently, it was reported that caspase-11 and AIP1 cooperatively promote cofilin-mediated actin depolymerization.Product Details
- Antibody Type
- Host Species
- Full length recombinant protein expressed in E Coli
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5 - 1 µg per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
- Li J, et al. 2007. Nature Cell Biology 9:276
AB_2063814 (BioLegend Cat. No. 645601)
- A protein of 67-kd WD-repeat protein. It contains as many as 10 WD repeats which is characterized by homologous sequence of around 40 amino acids with Trip-Asp(WD) at the carboxyl ends.
- Enhance actin filament disassembly in the presence of actin-depolymerizing factor cofilin.
- AIP1 binds cofilin/actin depolymerization factor.
- Caspase-11 interacts physically with AIP1 to promote cofilin-mediated actin depolymerization.
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure
- Antigen References
1. Voegtli WC, et al. 2003 J. Biol. Chem. 278:34373
2. Mohri K, et al. 2004. J. Biol. Chem. 279:31697
- Gene ID
- 22388 View all products for this Gene ID
- View information about AIP1 on UniProt.org
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