- B032F6 (See other available formats)
- Regulatory Status
- Other Names
- Epstein Barr virus induced gene 3, IL-27B, IL-35 subunit
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Epstein-Barr virus induced gene-3, also known as EBI3, is an IL-12 p40-related protein that can heterodimerize with IL-12 p35 to form IL-35, or with an IL-12 p35-related protein, p28, to form IL-27. It is produced by antigen-presenting cells such as B cells, monocytes, and dendritic cells following stimulation through TLR. It can regulate T cell differentiation and proliferation. Both IL-27 and IL-35 are anti-inflammatory cytokines that are able to inhibit Th17 generation, promote Th1 diferentiation, increase cytolytic potential of CD8+ T cells, and impact B cell differentiation and Ig production.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Purified human IL-27
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Product Citations
AB_2562879 (BioLegend Cat. No. 360903)
AB_2562880 (BioLegend Cat. No. 360904)
- Hematopoietin receptor family, subunit of IL-27 and IL-35
B cells, monocytes and dendritic cells
- Pro- and anti-inflammatory
- IL-27 p28 subunit, IL-35 p35 subunit
- Cell Type
- B cells, Dendritic cells, Monocytes
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Antigen References
1. Pflanz S, et al. 2002. Immunity. 16: 779.
2. Takeda A, et al. 2003. J. immunol. 170: 4886.
3. Pflanz S, et al. 2004. J. Immunol. 172: 2225.
4. Li MF, et al. 2013. Dev. Comp. Immunol. 41: 514.
- Gene ID
- 10148 View all products for this Gene ID
- View information about IL-27 IL-35 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
|PE anti-human IL-27/IL-35 EBI3 (monomer, dimer, heterodimer)||B032F6||ICFC|
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